Improving cognitive control in Parkinson's patients using electrical stimulation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of transcranial direct current stimulation (tDCS) on cognitive control in patients with Parkinson's disease who are undergoing dopaminergic treatment. The research aims to determine if cathodal stimulation of the Supplementary Motor Areas can enhance the ability to correct impulsive responses, which are often impaired in these patients. Participants will engage in a reaction time task, known as Simon's task, both with and without the stimulation to assess its impact on error correction. The study is designed as a single-center, single-blind, randomized trial.

Why it matters

Who can join: the full rules

Inclusion Criteria for Parkinsonien patients:

* Age\> 18 years old
* Idiopathic Parkinson's disease meeting the diagnostic criteria as defined by Ward and Gibb (1990)
* Patients usually taking dopaminergic treatment.
* No cognitive deterioration with: a Montreal Cognitive Assessment (MoCA) score ≥ 26
* Patient with Parkinson's disease in the advanced motor complications stage for which surgical treatment is being considered

Inclusion Criteria for healthy subjects

* Age\> = 18 years old
* Patient free from Idiopathic Parkinson's Disease
* No cognitive deterioration: MMSE (MiniMentalSate Evaluation)\> 26

Exclusion Criteria for both parkinsonien patients an healthy volunteers:

* Uncorrected altered visual acuity
* Dyschromatopsia (especially color blindness)
* Psychotropic treatment introduced or modified recently (\<1 month)
* Wearing a pacemaker (Pace Maker or Implantable Defibrillator)
* Pregnancy (verified by a urine pregnancy test for women of childbearing age)
* Other central nervous system disease (other parkinsonian syndrome, epilesia, stroke, etc.) or peripheral
* Intracranial metal implants on the cephalic stage and cochlear implant
* Untreated progressive mood or psycho-behavioral disorder
* Severe and poorly controlled eczema

Exclusion criteria for Parkinson's patients only:

* Significant and disabling abnormal movement, not allowing good acquisition of the EMG signal (tremors or dyskinesias)
* Wearer of a Deep Brain Stimulation device (CI at tDCS).

Where it's running

• Service Neurologie et pathologies du mouvement
  Marseille, France Recruiting

Study contacts

• Study coordinator: Frederique Fluchere, MD
• Email: frederique.fluchere@ap-hm.fr
• Phone: 0491389368

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.