Improving cognitive control in Parkinson's patients using electrical stimulation
Modulation of Cognitive Control Via Transcranial Continuous Electrical Stimulation of Additional Motor Areas in Parkinson's Patients
This study is testing if a special type of brain stimulation can help people with Parkinson's disease improve their ability to control impulsive actions while they are on their medication.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 72 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Assistance Publique Hopitaux De Marseille Academic / other |
| Locations | 1 site (Marseille) |
| Trial ID | NCT04897633 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of transcranial direct current stimulation (tDCS) on cognitive control in patients with Parkinson's disease who are undergoing dopaminergic treatment. The research aims to determine if cathodal stimulation of the Supplementary Motor Areas can enhance the ability to correct impulsive responses, which are often impaired in these patients. Participants will engage in a reaction time task, known as Simon's task, both with and without the stimulation to assess its impact on error correction. The study is designed as a single-center, single-blind, randomized trial.
Who should consider this trial
Good fit: Ideal candidates include adults over 18 with idiopathic Parkinson's disease who are on dopaminergic treatment and have no significant cognitive deterioration.
Not a fit: Patients with uncorrected visual acuity issues, recent changes in psychotropic treatment, or those with certain medical devices like pacemakers may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly improve cognitive control and reduce impulsivity in Parkinson's patients, enhancing their overall quality of life.
How similar studies have performed: Previous studies have shown promising results with tDCS in improving cognitive functions, suggesting potential success for this approach in Parkinson's disease.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria for Parkinsonien patients: * Age\> 18 years old * Idiopathic Parkinson's disease meeting the diagnostic criteria as defined by Ward and Gibb (1990) * Patients usually taking dopaminergic treatment. * No cognitive deterioration with: a Montreal Cognitive Assessment (MoCA) score ≥ 26 * Patient with Parkinson's disease in the advanced motor complications stage for which surgical treatment is being considered Inclusion Criteria for healthy subjects * Age\> = 18 years old * Patient free from Idiopathic Parkinson's Disease * No cognitive deterioration: MMSE (MiniMentalSate Evaluation)\> 26 Exclusion Criteria for both parkinsonien patients an healthy volunteers: * Uncorrected altered visual acuity * Dyschromatopsia (especially color blindness) * Psychotropic treatment introduced or modified recently (\<1 month) * Wearing a pacemaker (Pace Maker or Implantable Defibrillator) * Pregnancy (verified by a urine pregnancy test for women of childbearing age) * Other central nervous system disease (other parkinsonian syndrome, epilesia, stroke, etc.) or peripheral * Intracranial metal implants on the cephalic stage and cochlear implant * Untreated progressive mood or psycho-behavioral disorder * Severe and poorly controlled eczema Exclusion criteria for Parkinson's patients only: * Significant and disabling abnormal movement, not allowing good acquisition of the EMG signal (tremors or dyskinesias) * Wearer of a Deep Brain Stimulation device (CI at tDCS).
Where this trial is running
Marseille
- Service Neurologie et pathologies du mouvement — Marseille, France (Recruiting)
Study contacts
- Study coordinator: Frederique Fluchere, MD
- Email: frederique.fluchere@ap-hm.fr
- Phone: 0491389368
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.