Improving cognition and motivation in early psychosis
EPI-MINN: Targeting Cognition and Motivation in Coordinated Specialty Care for Early Psychosis: A National Comparison Study
This study tests a 12-week mobile program to see if it can help people with early psychosis improve their thinking skills and motivation compared to regular care.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 200 (estimated) |
| Ages | 15 Years to 40 Years |
| Sex | All |
| Sponsor | University of Minnesota Academic / other |
| Locations | 1 site (Minneapolis, Minnesota) |
| Trial ID | NCT05877716 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate a 12-week mobile intervention program designed to enhance cognitive functioning and motivation in individuals experiencing early psychosis. Participants will be recruited from coordinated specialty care clinics across the United States and will receive either the mobile intervention or standard community care. The program includes cognitive and social cognitive training, as well as a personalized app for motivational enhancement. The study will be conducted remotely, allowing participants to engage from home using their own electronic devices.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 15-40 who have experienced symptoms of psychosis within the last 5 years and are enrolled in an early psychosis coordinated specialty care clinic.
Not a fit: Patients who are not experiencing recent symptoms of psychosis or those with severe chronic illnesses that impede participation may not benefit from this study.
Why it matters
Potential benefit: If successful, this intervention could significantly improve cognitive functioning and motivation in patients with early psychosis, leading to better long-term outcomes.
How similar studies have performed: Previous studies have shown promising results with cognitive training in early psychosis, indicating that this approach has potential based on existing evidence.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged 15-40 (inclusive) * Is enrolled in an early psychosis coordinated specialty care clinic, or is receiving services by a mental health care professional. * Symptoms of psychosis started within the last 5 years * Is in good general physical health (e.g., not acutely ill or experiencing a sever/chronic illness that would impede their ability to complete study activities) * Fluent in spoken and written English * Estimated IQ at or above 70, as estimated by the Test My Brain matrices task * Participants will show overall clinical stability as determined by interview measures. Generally, participants who have not been hospitalized within the last 30 days, who have not had significant changes to medications, and do not have active suicidal ideation will be considered stable. * Has access to a smart phone or other mobile device to use the PRIME App * Has access to a computer or tablet to complete cognitive training exercises and study assessments Exclusion Criteria: * Unable to provide informed consent (i.e., cannot pass UBACC assessment) * Participant is under legal commitment to treatment or is under medical guardianship * Participated in significant cognitive training programs within the last 3 years * Diagnosed with a neurological disorder that may interfere with participation in the study * Clinically significant substance abuse that is impeding the participant's ability to participate fully during enrollment, assessment, or training (i.e., is unable to remain sober) * Risk of suicidal behavior
Where this trial is running
Minneapolis, Minnesota
- University of Minnesota Department of Psychiatry & Behavioral Sciences — Minneapolis, Minnesota, United States (Recruiting)
Study contacts
- Principal investigator: Sophia Vinogradov, MD — University of Minnesota Department of Psychiatry and Behavioral Sciences
- Study coordinator: Nate Olinger
- Email: epinetrct@umn.edu
- Phone: 612-403-4587
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.