Improving care for ICU patients to reduce delirium
Official title: Modified Hospital Elder Life Program at Intensive Care Unit: A Stepped-Wedge Cluster Randomized Controlled Trial
Run by National Taiwan University Hospital · NCT06054828 · Data updated 2026-11-12
This study is testing a new program in ICUs to see if it can help reduce delirium in patients on mechanical ventilation by improving their mental engagement, physical activity, and nutrition.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 266 (estimated) |
| Sponsor | National Taiwan University Hospital Academic / other |
| Locations | 1 site (Taipei, National Taiwan University) |
| Status | Recruiting |
| Started | September 5, 2023 |
| Main results expected | July 31, 2026 |
| Study ends | July 31, 2026 |
| Registry record updated | November 28, 2025 |
| Trial ID | NCT06054828 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older who are receiving mechanical ventilation and are expected to be intubated for more than 48 hours without pre-existing delirium or coma.
✕Probably not a fit
Patients placed on droplet or contact precautions, such as those with open TB, SARS, or COVID-19, may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to implement a modified Hospital Elder Life Program (mHELP@ICU) in intensive care units to address ICU delirium, which affects a significant number of patients on mechanical ventilation. The intervention focuses on enhancing cognitive engagement, physical activity, and nutritional support for critically ill patients. The study will assess the effectiveness of this nursing-driven intervention in reducing the incidence of delirium and improving patient outcomes, including cognitive function and mortality rates, three months after ICU admission. The research is divided into two phases, with the first phase ensuring accurate delirium assessments by ICU nurses using the Intensive Care Delirium Screening Checklist.
Why it matters
Potential benefit: If successful, this intervention could significantly reduce the incidence of delirium in ICU patients, leading to better cognitive and functional outcomes.
How similar studies have gone: Other studies have shown success with similar interventions aimed at reducing ICU delirium, indicating a promising approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria of the second phase * participants who are 18 years old or older. * participants who receive oral endotracheal intubation with mechanical ventilation and are expected intubation greater than 48 hours. * participants are free from delirium or coma before ICU admission. Exclusion Criteria of the second phase * participants who are placed on droplet or contact precautions (e.g., Open TB, SARS, COVID-19 )
Where it's running
-
Cheryl, Chia-Hui Chen, PhD
Taipei, National Taiwan University, Taiwan Recruiting
Study contacts
- Study coordinator: Chen Chia-Hui, PhD
- Email: cherylchen@ntu.edu.tw
- Phone: +886-2-23123456
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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A ketone supplement given by mouth or feeding tube is being tested to see if it can reduce delirium duration or occurrence in adults in the ICU compared with a placebo.
-
Virtual reality to prevent delirium in the ICU
This project will try daily 15-minute virtual reality sessions to see if they reduce delirium in high-risk, non-intubated adult surgical ICU patients.
-
Using wheat beer to prevent delirium in ICU patients
This study is testing if giving ICU patients at risk of delirium daily wheat beer instead of water can help prevent them from developing delirium.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.