Improving arm function and brain recovery in stroke patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of cranial nerve non-invasive neuromodulation combined with strength training on arm function and brain plasticity in individuals who have experienced a stroke. The approach involves assessing the excitability of the corticospinal pathway using transcranial magnetic stimulation (TMS) to tailor rehabilitation interventions based on individual recovery potential. Participants will undergo targeted training to enhance upper limb motor recovery, leveraging neuroplasticity to improve their quality of life and independence. The study aims to provide insights into the efficacy of this innovative rehabilitation strategy for chronic stroke survivors.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* be ≥18 years of age;
* have had a unilateral supratentorial stroke;
* be in a chronic stage of recovery (\>6 months);
* present some UL motor recovery (Fugl-Meyer Stroke Assessment \[FMA-UE\] score ≥25/66);
* are not involved in rehabilitation treatments.

Exclusion Criteria:

* significant spasticity at UL (score \>3 on the modified Ashworth scale);
* major sensory deficit at UL (a score \<25/34 on the Nottingham sensory assessment and a score \<6 on the vibration threshold assessment);
* hemineglect (\> 70% of unshaded lines on the same side as the motor deficit on the Line Cancellation test);
* apraxia (score \>2.5 on the Alexander test);
* a neurological disorder other than stroke-related;
* orthopedic problems at UL;
* cognitive impairment (score \<2/5 on the Mini-Cog);
* significant pain intensity at UL (a score ≥ 6/10 on the Visual Analog Pain Scale);
* absence of MEP (peak-to-peak MEP amplitude \<20μV);
* contraindications to CN-NINM and TMS.

Where it's running

• CRIR/Feil/Oberfeld Research Center; Centre intégré de santé et de services sociaux de Laval; Jewish Rehabilitation Hospital
  Laval, Quebec, Canada Recruiting
• Cirris
  Québec, Quebec, Canada Recruiting
• Centre de recherche sur le vieillissement
  Sherbrooke, Quebec, Canada Recruiting

Study contacts

• Principal investigator: Marie-Helene Milot, PhD — Université de Sherbrooke
• Study coordinator: Marie-Helene Milot, PhD
• Email: marie-helene.milot@usherbrooke.ca
• Phone: 819-780-2220

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Deep phenotyping to explore recovery in young adults after stroke

  This project will test whether a detailed health and sample-collection approach (deep phenotyping) is practical and acceptable for people aged 18–55 who have had a stroke.

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• Stem cell therapy for chronic stroke recovery

  This study is testing whether using a patient's own stem cells can help people with long-term stroke recovery feel better and improve their daily functioning.

  Recruiting Phase 2 Hokkaido University Hospital · Sapporo, Hokkaido · NCT06752720

• AI-based tools to help diagnose, treat and predict stroke outcomes across multiple hospitals

  This study tests AI-powered tools on real-world stroke patients to see if they can improve pre-hospital triage, diagnosis, and outcome prediction while data stay securely within each hospital.

  Recruiting at 2 sites Hospital Universitari Vall d'Hebron Research Institute · Leuven and 6 other locations · NCT07924371

• Web-based therapy using action observation and mirror therapy for arm weakness after stroke

  This trial tests whether a mobile telerehabilitation app delivering action observation therapy (AOT) alone or combined AOT with mirror therapy (AOT-MT) can improve upper limb function in people with subacute stroke.

  Recruiting Chang Gung Memorial Hospital · Taoyuan · NCT07921108

• Remote Ischaemic Conditioning for Fatigue After Stroke 2

  Aat least 12 weeks after stroke, adults with post-stroke fatigue will try a simple hand-arm cuff treatment at home to see if it helps reduce fatigue.

  Recruiting Phase 2 Sheffield Teaching Hospitals NHS Foundation Trust · Sheffield, South Yorkshire · NCT07914647

• Dual-task balance training plus computer-based cognitive training after stroke

  In adults who recently had a stroke, the study tests whether adding computerized cognitive exercises to balance training improves balance and other recovery outcomes.

  Recruiting Matia Foundation · San Sebastián, GUIPUZCOA · NCT07913620

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.