Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Improved MRI technique for detecting spinal cord lesions in multiple sclerosis

Official title: 3D OPTIMIZED WMN MPRAGE Increased Detection of Focal Spinal Cord Lesion in Multiple Sclerosis (WHINUME)

Run by University Hospital, Bordeaux · NCT05227092 · Data updated 2026-11-12

This study is testing a new MRI technique to see if it can find spinal cord lesions better than regular MRI scans in people with multiple sclerosis.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment60 (estimated)
SponsorUniversity Hospital, Bordeaux
Academic / other
Locations1 site (Bordeaux)
StatusRecruiting
StartedAugust 2, 2023
Main results expectedMay 1, 2026
Study endsMay 1, 2026
Registry record updatedJune 29, 2025
Trial IDNCT05227092 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults over 18 years old with clinically isolated syndrome (CIS) or relapsing-remitting multiple sclerosis (RRMS) who have experienced medullary symptoms for less than 6 months.

Probably not a fit

Patients with progressive multiple sclerosis or other neurological conditions, as well as those with contraindications to MRI, will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to compare a new 3D OPTIMIZED MPRAGE WMN MRI sequence with conventional imaging techniques for detecting spinal cord lesions in patients with multiple sclerosis. Participants will undergo MRI scans at both cervical and thoracic levels using various sequences, including the new optimized technique. The goal is to assess whether the new sequence provides better sensitivity and specificity in identifying lesions, which could enhance diagnosis and treatment planning for multiple sclerosis patients.

Why it matters

Potential benefit: If successful, this study could lead to more accurate detection of spinal cord lesions in multiple sclerosis, improving patient management and outcomes.

How similar studies have gone: While there have been advancements in MRI techniques for brain imaging in multiple sclerosis, the specific application of the 3D OPTIMIZED WMN MPRAGE sequence for spinal cord lesions is relatively novel and has not been extensively tested.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients older than 18 years old
* CIS or RRMS
* Medullary symptomatology less than 6 months
* With or without an objective lesion on a subsequent MRI scan
* Signed the Informed Consent

Exclusion Criteria:

* Pregnant or potentially pregnant women
* Breastfeeding woman
* Contraindications to MRI
* Other diagnosis (Neuro-myelitis spectrum disease or Progressive Multiple Sclerosis)
* Surgical history on the spinal cord or lumbar spine
* Patient under legal protection

Where it's running

  • CHU de Bordeaux
    Bordeaux, France
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.