Improved MRI technique for detecting spinal cord lesions in multiple sclerosis
Official title: 3D OPTIMIZED WMN MPRAGE Increased Detection of Focal Spinal Cord Lesion in Multiple Sclerosis (WHINUME)
Run by University Hospital, Bordeaux · NCT05227092 · Data updated 2026-11-12
This study is testing a new MRI technique to see if it can find spinal cord lesions better than regular MRI scans in people with multiple sclerosis.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | University Hospital, Bordeaux Academic / other |
| Locations | 1 site (Bordeaux) |
| Status | Recruiting |
| Started | August 2, 2023 |
| Main results expected | May 1, 2026 |
| Study ends | May 1, 2026 |
| Registry record updated | June 29, 2025 |
| Trial ID | NCT05227092 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults over 18 years old with clinically isolated syndrome (CIS) or relapsing-remitting multiple sclerosis (RRMS) who have experienced medullary symptoms for less than 6 months.
✕Probably not a fit
Patients with progressive multiple sclerosis or other neurological conditions, as well as those with contraindications to MRI, will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to compare a new 3D OPTIMIZED MPRAGE WMN MRI sequence with conventional imaging techniques for detecting spinal cord lesions in patients with multiple sclerosis. Participants will undergo MRI scans at both cervical and thoracic levels using various sequences, including the new optimized technique. The goal is to assess whether the new sequence provides better sensitivity and specificity in identifying lesions, which could enhance diagnosis and treatment planning for multiple sclerosis patients.
Why it matters
Potential benefit: If successful, this study could lead to more accurate detection of spinal cord lesions in multiple sclerosis, improving patient management and outcomes.
How similar studies have gone: While there have been advancements in MRI techniques for brain imaging in multiple sclerosis, the specific application of the 3D OPTIMIZED WMN MPRAGE sequence for spinal cord lesions is relatively novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients older than 18 years old * CIS or RRMS * Medullary symptomatology less than 6 months * With or without an objective lesion on a subsequent MRI scan * Signed the Informed Consent Exclusion Criteria: * Pregnant or potentially pregnant women * Breastfeeding woman * Contraindications to MRI * Other diagnosis (Neuro-myelitis spectrum disease or Progressive Multiple Sclerosis) * Surgical history on the spinal cord or lumbar spine * Patient under legal protection
Where it's running
-
CHU de Bordeaux
Bordeaux, France Recruiting
Study contacts
- Study coordinator: Vincent Dousset, MD, PhD
- Email: vincent.dousset@chu-bordeaux.fr
- Phone: +335 56 79 56 04
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.