Improved method to measure bone blood flow with total-body PET/CT in healthy adults
Official title: Development of an Improved Method of Measuring Total Body Bone Perfusion Using Total-body PET/CT
Run by King's College London · NCT07860346 · Data updated 2026-11-12
This study tests whether a whole-body PET/CT scan using a safe radioactive tracer can measure bone blood flow in healthy volunteers aged over 50.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 50 Years and up |
| Sex | All |
| Enrollment | 10 (estimated) |
| Sponsor | King's College London Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (London) |
| Status | Recruiting |
| Started | September 23, 2026 |
| Main results expected | October 31, 2027 |
| Study ends | October 31, 2027 |
| Registry record updated | October 6, 2026 |
| Trial ID | NCT07860346 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Healthy volunteers aged over 50 without metabolic or metastatic bone disease, with suitable venous access and ability to stay still for 60 minutes.
✕Probably not a fit
Individuals with metal implants, claustrophobia, pregnancy, uncontrolled hypertension, or body size outside specified limits may not benefit from or qualify for this imaging approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective, single-center, exploratory pilot study conducted at King's College London. Ten healthy volunteers (5 men and 5 women, all over 50) will undergo a 1-hour dynamic total-body PET/CT scan after a bolus injection of 90 MBq of [18F]-sodium fluoride to measure bone perfusion (K1) and regional bone plasma clearance (Ki). Five blood samples will accompany the scan to verify arterial input function and adjust measurements for plasma concentration. The study uses the latest high-sensitivity total-body PET/CT technology to improve accuracy of bone perfusion assessment compared with older scanners.
Why it matters
Potential benefit: If successful, this approach could provide a more accurate and convenient way to measure bone blood flow in clinical research and potentially aid in understanding bone diseases.
How similar studies have gone: Previous animal studies and early human imaging using [18F]-NaF with PET suggested potential for measuring bone perfusion, and newer total-body PET/CT systems may improve accuracy.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 5 male and 5 female healthy volunteers aged over 50 years * No metabolic bone disease (e.g. osteoporosis) * No metastatic bone disease * Good venous access * Must be able to lie flat and remain motionless for the duration of the scan (60 minutes) * Good bladder control Exclusion Criteria: * Over 1.85 metres (6.1 feet) in height to ensure adequate skeletal coverage * Over 95 kg (15 stone) in weight to ensure image quality * Claustrophobia * Uncontrolled high blood pressure * Presence of any metal in the body or heart pacemaker * Pregnant women * Not currently or previously been involved within the last 12 months on trials investigating other imaging methods involving ionising radiation
Where it's running
-
King's College London
London, United Kingdom Recruiting
Study contacts
- Study coordinator: Amelia Moore, PhD
- Email: amelia.moore@kcl.ac.uk
- Phone: +44 0207 188 4092
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.