ReHIIT Prehabilitation in Healthy Adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study explores whether a combined resistance and high‑intensity interval training (ReHIIT) program can produce measurable improvements in fitness and physiology within a short prehabilitation window. It is conducted in healthy adult volunteers to establish baseline responses that can later be compared with cancer patients facing surgery. Participants attend sessions at the University of Nottingham and Royal Derby Hospital, with a minimum of eight exercise sessions and two assessments. The trial emphasizes safety and feasibility, aiming to inform future cancer prehabilitation strategies amidst time constraints before surgery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Participant is willing and able to give informed consent for participation in the study.
* Availability and willingness to attend the Royal Derby Hospital site for a minimum of 8 exercise sessions and 2 assessment sessions across the study period.

Exclusion Criteria:

* BMI \<18 or \>35 kg/m2
* Known active cance
* Known metabolic disease
* Current known neurological or musculoskeletal conditions (e.g. epilepsy)
* Active known cardiovascular, cerebrovascular or respiratory disease - e.g:
* Uncontrolled hypertension (systolic BP \> 160 mmHg or diastolic BP \>100 mmhg)
* Myocardial infarction within the last 6 months or unstable angina
* Heart failure (New York Heart association Class III/IV)
* Arrhythmia
* Right to left cardiac shunt
* Aneurysm of a named blood vessel
* COPD
* Pulmonary hypertension
* Exercise-induced or brittle asthma
* Previous stroke/transient ischaemic attack
* Abnormal ECG results (at the discrepancy of the study doctor)
* Patients who are unable to undergo CPET based on ATS/ACSS guidelines \^
* Pre-existing clotting disorder known to the participant or anticoagulant use
* Family history of severe bleeding requiring medical intervention
* Participation in a research study in the last 3 months involving invasive procedures or an inconvenience allowance (ALL UoN FMHS UREC approved studies)
* Pregnant or breastfeeding

Where it's running

• Medical School, University of Nottingham, Royal Derby Hospital
  Derby, Derbyshire, United Kingdom Recruiting

Study contacts

• Principal investigator: Professor Bethan E Phillips — University of Nottingham
• Study coordinator: Tyler J Daubrah-Scott, MRes, BSc (Hons)
• Email: tyler.daubrah-scott@nottingham.ac.uk
• Phone: 01332 724676

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.