Impact of root canal treatment on kidney function and inflammation in patients with chronic kidney disease and apical periodontitis
Potential Effects of Non-surgical Endodontic Treatment on Periapical Healing, Inflammatory Markers, and Kidney Function Indicators in Chronic Kidney Disease Patients With Apical Periodontitis- Interventional Study.
This study is testing if getting a root canal can help improve kidney function and reduce inflammation in people with chronic kidney disease who also have dental issues.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 74 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Postgraduate Institute of Dental Sciences Rohtak Academic / other |
| Locations | 1 site (Rohtak, Haryana) |
| Trial ID | NCT06446011 on ClinicalTrials.gov |
What this trial studies
This prospective study aims to evaluate the effects of non-surgical root canal treatment on periapical healing and inflammatory markers in patients with chronic kidney disease (CKD) and healthy individuals suffering from apical periodontitis. The study will assess clinical and radiographic success rates at baseline, 6 months, and 12 months, while also measuring changes in inflammatory markers and kidney function indicators at various follow-up points. By exploring the relationship between oral health and systemic conditions, the research seeks to determine if improving dental health can positively influence renal function and inflammatory status in CKD patients.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older with chronic kidney disease stages 1-5 and at least 12 natural teeth, who have a periapical index score of 3 or higher.
Not a fit: Patients with other systemic disorders, significant periodontal disease, or those currently taking medications that affect inflammatory markers may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment protocols that enhance both oral and systemic health in patients with chronic kidney disease.
How similar studies have performed: While the relationship between oral health and systemic diseases has been noted, this specific approach of assessing non-surgical root canal treatment in CKD patients is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1- Known patient of Chronic Kidney Disease \[CKD Stages 1,2,3,4,5 with mature permanent teeth. 2. Age18year or older . 3. ≥ to 12 natural teeth (excluding 3rd molars) 4 The periapical index (PAI) was used to evaluate the periapical status patients with PAI ≥3 are included in the study. Exclusion Criteria: 1. Patients having systemic disorders other than chronic kidney disease (e.g HIV; Diabetes mellitus; Coronary heart disease; no history of secondary hyperparathyroidism) 2. Patients with periodontitis , pocket depth and CAL\>5mm( stage 3 ,4) will be excluded. 3. Pregnancy; lactation \& contraceptives. 4. Patients taking antibiotics, statins, corticosteroids and aspirin which can affect the level of inflammatory markers in past one month.
Where this trial is running
Rohtak, Haryana
- Pgids — Rohtak, Haryana, India (Recruiting)
Study contacts
- Principal investigator: Himanshi Verma, Mds — Pgids,rohtak
- Study coordinator: Shweta Mittal, Mds
- Email: shwetagoelendo@gmail.com
- Phone: 9255596960
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.