Impact of Premature Ventricular Complexes on Respiratory and Physical Health

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study compares adults with symptomatic premature ventricular complexes to healthy controls to explore respiratory function, respiratory muscle strength, cough strength, handgrip strength, physical activity, and quality of life. Participants will undergo clinical assessments, questionnaires, and measurements to characterize these parameters. The study also aims to identify differences between PVC patients and controls and contribute new data to the field.

Why it matters

Who can join: the full rules

Inclusion Criteria for Individuals with Premature Ventricular Complexes (PVCs):

* Aged between 18 and 80 years
* Presence of symptomatic premature ventricular complexes resistant to ≥1 antiarrhythmic medication (including β-blockers and calcium channel blockers)
* Premature ventricular complex burden ≥10%
* Ventricular arrhythmias originating from any focus within the right or left ventricle
* Physically able to participate in all study assessments
* Willingness to participate in the study by providing written informed consent

Inclusion Criteria for Control Group Participants:

* Aged between 18 and 80 years
* Healthy individuals
* Willingness to participate in the study
* Physically able to participate in all study assessments

Exclusion Criteria for Individuals with Premature Ventricular Complexes (PVCs):

* Left ventricular ejection fraction (LVEF) \<45% unless PVC-induced cardiomyopathy is documented (defined as a \>15% improvement in LVEF following reduction of PVC burden through pharmacological therapy or ablation)
* Progressive decline in LVEF within the last 4 months, regardless of etiology
* Severe heart failure classified as New York Heart Association (NYHA) Class ≥III
* Ventricular arrhythmias attributed to underlying structural heart disease, known myocardial scar, or myocarditis
* Change in the dosage of antiarrhythmic medications (including β-blockers and calcium channel blockers) within 2 months prior to enrollment
* Failed catheter ablation within 3 months prior to enrollment
* Known thyroid disorders or individuals undergoing renal dialysis
* Life expectancy \<12 months
* Presence of angina pectoris
* Diagnosis of chronic obstructive pulmonary disease (COPD) or asthma
* Resting heart rate \>120 beats/min
* Resting systolic blood pressure ≥180 mmHg
* Resting diastolic blood pressure ≥100 mmHg
* Resting peripheral oxygen saturation ≤90%

Exclusion Criteria for Control Group Participants:

* Presence of premature ventricular complexes
* Presence of any acute or chronic medical condition

Where it's running

• Izmir Democracy University
  Izmir, Turkey (Türkiye) Recruiting

Study contacts

• Principal investigator: Esra Sude Akin — Izmir Democracy University
• Study coordinator: Gülşah Barği
• Email: gulsahbargi35@gmail.com
• Phone: +90 232 299 0739

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Severe Complications During VT/PVC Ablation

  This study looks at real-world cases to see what severe complications occur during VT or PVC ablations and how patients are managed afterward.

  Recruiting at 25 sites University Hospital, Basel, Switzerland · Chicago, Illinois and 24 other locations · NCT07777744

• Catheter ablation vs. anti-arrhythmic drugs for PVCs

  This study tests whether catheter ablation or anti-arrhythmic medications are better at reducing PVC symptoms and improving quality of life for adults with a normal heart function.

  Recruiting Western Sydney Local Health District · Westmead, New South Wales · NCT07445334

• Using flecainide to treat frequent premature ventricular contractions and related heart issues

  This study is testing if the heart medication flecainide can help adults with frequent heartbeats and related heart issues who can't or don't want to have a procedure called catheter ablation.

  Recruiting at 3 sites University of Athens · Pátrai, Achaia and 5 other locations · NCT06949748

• Evaluating the need for cardiac MRI in patients with premature ventricular complexes

  This study is trying to see if heart scans are really needed for people with premature ventricular complexes to find any hidden heart problems.

  Recruiting Centre Hospitalier Universitaire, Amiens · Salouël · NCT06801743

• Using Transcutaneous Auricular Vagus Nerve Stimulation for treating frequent premature ventricular complexes

  This study is testing if a new treatment using electrical stimulation of the ear can help people with frequent heart palpitations feel better and reduce their symptoms.

  Recruiting Guang'anmen Hospital of China Academy of Chinese Medical Sciences · Beijing, Beijing Municipality · NCT04415203

• Kardi Ai ECG telemetry monitoring for detecting heart rhythm problems

  The Kardi Ai wearable ECG system will be tested to see if it can accurately detect irregular heart rhythms in adults with or suspected of having heart rhythm disorders.

  Recruiting at 2 sites KARDI AI Technologies s.r.o. · Olomouc, Czechia and 1 other locations · NCT07018648

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.