Using Transcutaneous Auricular Vagus Nerve Stimulation for treating frequent premature ventricular complexes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the efficacy and safety of Transcutaneous Auricular Vagus Nerve Stimulation (TAVNS) in patients experiencing frequent premature ventricular complexes (FPVCs). Ninety participants will be randomly assigned to receive either TAVNS combined with usual care or a sham-TAVNS treatment alongside usual care for a duration of six weeks. The primary outcome is the proportion of participants achieving a 50% reduction in 24-hour PVCs after treatment, with secondary outcomes assessing further reductions and symptom changes. Follow-up will occur for 12 weeks post-treatment to monitor ongoing effects.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosed as frequent premature ventricular contractions;
* 2 ≤ Lown level ≤ 4A;
* 18 ≤ age ≤ 75;
* Volunteered to participant

Exclusion Criteria:

* Severe valvular disease, congenital heart disease, pericardial disease, hypertrophic cardiomyopathy, unstable angina pectoris, acute myocardial infarction, myocarditis, aneurysm, congestive heart failure decompensation period (NYHA grade III or VI), cardiogenic shock, cerebrovascular disease, hematopoietic system disease, severe mental disease;
* Bradycardia, including pathologic sinus node syndrome, degree II or greater atrioventricular block;
* Those who have already had pacemaker or percutaneous coronary intervention, or who plan to have pacemaker or percutaneous coronary intervention;
* Pregnant or lactating women;
* Local sensory deficit, or allergic to current;
* May be allergic to percutaneous patches；
* Blood pressure ≤ 90/60 mmHg;
* Those who have participated in other clinical trials within 3 months.

Where it's running

• Guang'anmen Hospita, China Academy of Chinese Medical Sciences
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Principal investigator: Jiani Wu — Guang'anmen Hospital of China Academy of Chinese Medical Sciences
• Study coordinator: Jiani Wu
• Email: jiani_wu@aliyun.com
• Phone: +8613426116653

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Evaluating the need for cardiac MRI in patients with premature ventricular complexes

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.