Impact of neurochecks on cognitive outcomes in older patients with brain injury

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research investigates how the frequency of neurological examinations, known as neurochecks, affects cognitive outcomes and delirium in older patients with acute intracerebral hemorrhage. Patients will be randomized to receive either hourly or every-other-hour neurochecks in the NeuroICU, where specialized teams provide care. The study aims to determine if adjusting the frequency of these checks can mitigate the risk of delirium and improve long-term cognitive health. Data will be collected on patient demographics, sleep quality, and clinical outcomes throughout their ICU stay.

Why it matters

Who can join: the full rules

Inclusion Criteria (Part 1):

1. Adult patients (age \>18 years) with spontaneous acute \<45cc in volume with radiographic and clinical stability for ≥6 hours following admission to the ICU. These criteria are based on the literature and experience of the investigative team.
2. Additional intraventricular hemorrhage (with or without external ventricular drain) is allowable.
3. Only first admission to the NeuroICU during the hospitalization will be eligible.

Inclusion criteria (Part 2):

a. any patient included in part 1 alive at 6 months post-discharge

Exclusion Criteria:

1. Patients with unstable intracranial bleeding
2. Patients with known history of intracranial neurological injury
3. Pre-existing cognitive impairment (known or highly suspected based on family-provided history, Activities of Daily Living Questionnaire)
4. Pre-existing diagnosed sleep disorder
5. Comatose or heavily sedated
6. Death expected within 30 days or other terminal illness
7. ICH score \>4 (equivalent to mortality risk \>72%)
8. Pregnancy
9. Incarcerated
10. Non-English or non-Spanish speaking

Where it's running

• UC San Diego Health
  San Diego, California, United States Recruiting

Study contacts

• Study coordinator: Jamie N LaBuzetta
• Email: jlabuzetta@ucsd.edu
• Phone: 18582491331

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.