Impact of initial periodontal therapy on gum health and quality of life in smokers and non-smokers

Change in Gingival Volume and Quality of Life Due to Initial Periodontal Therapy in Smokers

Not applicable Interventional University of Rijeka · NCT05719519

This study is testing how initial gum treatment affects gum health and quality of life for smokers and non-smokers with gum disease.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment60 (estimated)
Ages18 Years and up
SexAll
SponsorUniversity of Rijeka Academic / other
Locations1 site (Rijeka)
Trial IDNCT05719519 on ClinicalTrials.gov

What this trial studies

This study aims to evaluate the changes in gingival volume and quality of life in individuals with periodontitis undergoing initial periodontal therapy. It will compare the outcomes between non-smokers and cigarette smokers, with a focus on how these groups respond to treatment. A total of 60 subjects will participate, with 30 from each group, and will undergo clinical examinations and 3D intraoral scanning before and after therapy. Quality of life will be assessed through a validated questionnaire at the start and 8 weeks post-treatment.

Who should consider this trial

Good fit: Ideal candidates include adults diagnosed with periodontitis, both smokers and non-smokers.

Not a fit: Patients who have had previous periodontal treatment or those with systemic conditions affecting periodontal health may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could enhance understanding of how smoking affects periodontal treatment outcomes and improve quality of life for patients with periodontitis.

How similar studies have performed: While there have been studies on periodontal therapy, this specific comparison between smokers and non-smokers regarding gingival volume changes is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* periodontitis
* cigarette smokers
* non smokers

Exclusion Criteria:

* previous periodontal treatment
* pregnancy
* minors
* antibiotic therapy in the last 6 months
* patients with ortho appliances
* patients using drugs that affect gingival volume
* immunosuppressive therapy
* systemic conditions that affects periodontal tissues and therapy

Where this trial is running

Rijeka

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Periodontitis3D imaginggingivanonsurgical periodontal debridementperiodontitisquality of lifesmoking
Last reviewed 2026-06-10 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.