Impact of glaucoma on visual-motor skills

Exploring the Effects of Primary Open-Angle Glaucoma on Visual-Motor Coordination

This study is testing how primary open-angle glaucoma affects everyday tasks like reaching for objects and avoiding obstacles to better understand its impact on patients' daily lives.

Quick facts

• Study type: Observational
• Enrollment: 200 (estimated)
• Ages: 18 Years to 75 Years
• Sex: All
• Sponsor: Zhongshan Ophthalmic Center, Sun Yat-sen University (Academic / other)
• Locations: 1 site (Guangzhou, Guangdong)
• Trial ID: NCT06692205 on ClinicalTrials.gov

What this trial studies

This observational study aims to objectively assess how primary open-angle glaucoma affects patients' visual-motor coordination during daily activities. By using a motion capture system with lightweight reflective markers attached to participants' limbs, the study quantifies various indicators of planning, execution, and control in tasks such as object grasping and obstacle avoidance. The goal is to provide a more accurate evaluation of the disease's impact on patients' daily abilities compared to traditional visual function assessments and subjective questionnaires. This approach seeks to enhance understanding of the functional limitations caused by glaucoma and inform treatment strategies.

Who should consider this trial

Good fit: Ideal candidates include adults aged 18 to 75 diagnosed with primary open-angle glaucoma who meet specific visual acuity and stereoscopic vision criteria.

Not a fit: Patients with cognitive or psychological dysfunction, hearing impairment, or other conditions that hinder normal communication and assessment may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved assessments of visual function in glaucoma patients, ultimately enhancing their quality of life.

How similar studies have performed: While the approach of using motion capture for assessing visual-motor coordination is innovative, similar studies have shown promise in objectively evaluating functional impairments in other conditions.

Eligibility criteria

Inclusion Criteria:

1.1 Inclusion criteria of primary open-angle glaucoma group:

1. Age between 18 and 75 years;
2. Diagnosed with primary open-angle glaucoma, with no anti-glaucoma surgery scheduled within ±1 month;
3. Best corrected visual acuity in one eye ≥ 6/12;
4. Stereoscopic vision ≥ 1000 seconds of arc;
5. Able to clearly communicate and cooperate with the completion of relevant assessments and data collection.

1.2 Inclusion criteria of healthy controls：

1. Age between 18 and 75 years;
2. No history of eye disease other than refractive error and cataract;
3. Best corrected visual acuity in both eyes ≥ 6/12;
4. Stereoscopic vision ≥ 1000 seconds of arc;
5. Able to clearly communicate and cooperate with the completion of relevant assessments and data collection.

Exclusion Criteria:

1.1 Exclusion criteria for primary open-angle glaucoma group:

1. Individuals with cognitive dysfunction, psychological dysfunction, hearing impairment, or other conditions that prevent normal communication;
2. Presence of physical motor dysfunction, hyperthyroidism or hypothyroidism, malignant tumors, heart disease, or other systemic diseases;
3. Presence of other ocular conditions affecting visual function (except cataract and refractive error), such as age-related macular degeneration, diabetic retinopathy, optic neuropathy, retinal vascular disease, etc.;
4. Pregnant or lactating women.

1.2 Exclusion criteria for healthy controls：

1. Individuals with cognitive dysfunction, psychological dysfunction, hearing impairment, or other conditions that prevent normal communication;
2. Presence of physical motor dysfunction, hyperthyroidism or hypothyroidism, malignant tumors, heart disease, or other systemic diseases;
3. Presence of other ocular conditions affecting visual function (except cataract and refractive error), such as age-related macular degeneration, diabetic retinopathy, optic neuropathy, retinal vascular disease, etc.;
4. Pregnant or lactating women.

Where this trial is running

Guangzhou, Guangdong

• Zhongshan Opthalmic Center, Sun Yat-sen University — Guangzhou, Guangdong, China (Recruiting)

Study contacts

• Study coordinator: Yehong Zhuo

Conditions Primary Open-angle Glaucoma; Visual-motor coordination; glaucoma