Impact of Bariatric Surgery on Insulin Sensitivity and Energy Metabolism

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates how bariatric surgery affects insulin sensitivity, energy metabolism, and ectopic lipid storage in patients with obesity. It aims to understand the relationship between hepatic and muscular energy metabolism disorders and the degree of liver inflammation in obese individuals. The study will explore the mechanisms that lead to improved glucose tolerance following bariatric surgery, focusing on lipid metabolism and insulin signaling. Participants will be monitored for changes in their metabolic health post-surgery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged ≥ 20 years- ≤ 70 years
* BMI 20- 25 kg/m 2 normal- weight group
* BMI 35- 39,9 kg/m 2 (Obesity grade 2)
* BMI \>40 kg/m 2 (Obesity grade 3)

Exclusion Criteria:

* Acute illness 2 weeks before start of examination
* Autoimmune or Immune disorder diseases (Leukozyten \< 5000/µl
* Renal insufficiency (Kreatin \> 1,5 mg/dl)
* Heart disease, condition after heart attack
* Anemia (Hb \<12g/l, controlled before every day of examination) or blood donations 4weeks before examination.
* Participation in another trial within the last 2 weeks
* Pharmacological- immunotherapy (Cortisol, Antihistaminika, ASS)
* Thyroid disorders
* Glitazone Therapy
* Pregnancy, Lactation, Menstruation
* Smoking cigarettes, Alcohol- and drug abuse
* Psychiatric disorders
* Risk for/ or diagnosed HIV/ AIDS or Hepatitis B/C
* Liver disease, which are not caused by non- alcoholic steato- hepatitis
* Working on night shifts or irregular rhythm of night- day
* Impaired wound healing or clotting disorders
* Allergic reaction to local anesthetics
* Malignant cancer

Where it's running

• German Diabetes Center
  Düsseldorf, North Rhine-Westphalia, Germany Recruiting

Study contacts

• Principal investigator: Michael Roden, Prof., MD — German Diabetes Center
• Study coordinator: Sabine Kahl, MD
• Email: sabine.kahl@ddz.de
• Phone: 0049211-3382

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.