Impact of bariatric surgery on how quetiapine is processed in the body
Bariatric Surgery and Pharmacokinetics Quetiapine: BAR-MEDS Quetiapine
Norwegian University of Science and Technology · NCT03449472
This study looks at how bariatric surgery changes the way the body processes quetiapine, a medication for mental health, to help doctors better manage treatment for patients who have had the surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 12 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | Norwegian University of Science and Technology (other) |
| Locations | 1 site (Trondheim) |
| Trial ID | NCT03449472 on ClinicalTrials.gov |
What this trial studies
This observational study investigates how bariatric surgery, specifically gastric bypass and sleeve gastrectomy, affects the pharmacokinetics of quetiapine, a medication used to treat certain mental health conditions. It aims to understand changes in gastric pH, gastric emptying time, and gastrointestinal transit time that may influence the biological availability of quetiapine. By examining these factors, the study seeks to provide insights into medication management for patients undergoing bariatric surgery.
Who should consider this trial
Good fit: Ideal candidates are Norwegian citizens preparing to undergo gastric bypass or sleeve gastrectomy in Central Norway.
Not a fit: Patients who have previously undergone resections in the gastrointestinal tract may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved medication dosing and effectiveness for patients undergoing bariatric surgery.
How similar studies have performed: While there is limited research on this specific interaction, studies on pharmacokinetics post-bariatric surgery have shown varying results, indicating a need for further investigation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Preparing to undergo gastric bypass or sleeve gastrectomy in Central Norway * Being a Norwegian citizen Exclusion Criteria: * Having previously undergone resections in the GI-tract
Where this trial is running
Trondheim
- St. Olavs University Hospital — Trondheim, Norway (RECRUITING)
Study contacts
- Principal investigator: Magnus Strømmen, MSc — St. Olavs Hospital
- Study coordinator: Magnus Strømmen, MSc
- Email: magnus.strommen@stolav.no
- Phone: 0047 72829970
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Obesity, Morbid, Bariatric surgery, Gastrointestinal tract, Biological availability, Pharmacokinetics, Quetiapine fumarate