Immersive Virtual Reality in Upper-Limb Rehabilitation After Stroke

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center, prospective, randomized, open-label trial with blinded endpoint assessment evaluates if combining conventional rehabilitation with immersive virtual reality improves upper-limb motor function, functional status, and quality of life in adults with recent ischemic or intracerebral hemorrhagic stroke. It also explores whether IVR alters blood biomarkers of neuroplasticity and whether specific genetic polymorphisms influence rehabilitation response. Participants will be adults within seven days of stroke onset who have upper-limb mobility impairment and are continuing intensive rehabilitation after discharge. The study will compare CR alone versus CR plus IVR over short and long-term follow-up, with outcomes including motor function and prognosis, and will collect biomarker and genetic data to identify predictors of recovery.

Why it matters

Who can join: the full rules

Inclusion Criteria: Diagnosis of ischemic stroke or intracerebral hemorrhage. Age \> 18 years. \< 7 days between stroke onset and inclusion in the study. Impairment of mobility in the right or left upper limb due to stroke. After hospital discharge, patients continue an intensive conventional rehabilitation (ICR) program at their referral rehabilitation center (MUTUAM).

Ability to understand and sign the study informed consent form (ICF) and the IDIBGI Biobank informed consent form.

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Exclusion Criteria:

Previous upper limb disability (neurological or non-neurological cause). Previous dementia or any disease with a life expectancy of less than 1 year. Language comprehension difficulties. Difficulty remembering exercise instructions. History of photosensitive epilepsy.

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Where it's running

• Hospital Dr Josep Trueta
  Girona, Spain Recruiting

Study contacts

• Study coordinator: Yolanda Silva, MD PhD
• Email: ysilva.girona.ics@gencat.cat
• Phone: 34972940262

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.