Immediate effects of different atrial pacing sites on P-wave characteristics

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective, single-center, non-randomized study compares how short-term pacing from multiple atrial sites affects atrial electrical activation as seen on surface ECG. During standard pacemaker implantation, patients will receive sequential pacing from the right atrial appendage, atrial septum, Bachmann's bundle area, and high/low posterosuperior bundle regions with ECG recorded at each site. Primary analysis will examine differences in P-wave duration across sites; secondary analyses will evaluate P-wave morphology and polarity to identify the pacing location that most closely mimics physiological atrial activation. The goal is to inform optimal atrial lead placement to improve atrial activation sequencing and synchrony.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years
* Sinus rhythm at baseline
* Indication for permanent pacemaker implantation with planned atrial lead placement
* Willing and able to provide written informed consent

Exclusion Criteria:

* Long-standing persistent or permanent atrial fibrillation, or prior atrioventricular node ablation
* Prior cardiac implantable electronic device (CIED) requiring revision, replacement, or upgrade
* Indication for implantable cardioverter-defibrillator (ICD) or cardiac resynchronization therapy defibrillator (CRT-D)
* Significant valvular heart disease, cardiomyopathy, or prior cardiac surgery
* Angina or acute myocardial infarction within 3 months before enrollment
* Chronic use of antiarrhythmic drugs
* Severe hepatic or renal dysfunction, or other serious systemic diseases
* Participation in another clinical study that may interfere with the objectives of this study

Where it's running

• Tong Ren Hospital, Shanghai Jiaotong University School of Medicine
  Shanghai, Shanghai Municipality, China Recruiting
• Affiliated Hospital of Zunyi Medical College
  Zunyi, Guizhou, China Not yet recruiting

Study contacts

• Study coordinator: Zhaohui Qiu
• Email: qzh3503@shtrhospital.com
• Phone: +862152039999

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Evaluating Pacing Dependency After Aortic Valve Replacement

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.