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Clinical trial No longer in our active list Observational Ages 18 and up

Identifying thresholds for symptom relief in stable angina

Official title: Finding the Invasive Haemodynamic Threshold for Symptom Relief in Stable Angina

Run by Imperial College London · NCT05459051 · Data updated 2026-05-14

This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.

This study is testing if certain blood flow measurements can help relieve chest pain in patients with stable angina who are considering a heart procedure.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment58 (estimated)
SponsorImperial College London
Academic / other
Locations6 sites (Basildon and 5 other locations)
Trial IDNCT05459051 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults eligible for PCI with significant single-vessel coronary stenosis and evidence of ischaemia.

Probably not a fit

Patients with multivessel disease, significant left main stem disease, or those who have had recent acute coronary syndrome may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to determine the invasive haemodynamic thresholds associated with symptom relief in patients with stable angina. It involves a randomized, double-blinded, placebo-controlled approach to assess the fractional flow reserve (FFR) and non-hyperemic pressure ratio (NHPR) in 58 patients. Participants will undergo both rest and exercise physiological assessments to evaluate their angina symptoms under controlled conditions. The study focuses on patients eligible for percutaneous coronary intervention (PCI) due to significant coronary stenosis.

Why it matters

Potential benefit: If successful, this study could lead to improved management strategies for patients suffering from stable angina by identifying specific thresholds for symptom relief.

How similar studies have gone: Previous studies have explored similar physiological assessments in angina, but this specific approach to identifying invasive thresholds is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Eligibility for percutaneous coronary intervention (PCI) due to angina or angina-equivalent symptoms on exertion
* Anatomical evidence of significant single-vessel coronary stenosis defined by either:

  * ≥70% stenosis on invasive coronary angiography (ICA)
  * Severe stenosis on CT coronary angiography (CTCA)
* Physiological evidence of ischaemia with a positive test on at least one of the following:

  * Stress echocardiography
  * Cardiac magnetic resonance perfusion
  * Myocardial perfusion scintigraphy
  * Invasive metrics of coronary physiology

Exclusion Criteria:

* Age \<18 years
* Recent acute coronary syndrome
* Previous coronary artery by-pass graft
* Significant left main stem disease
* Multivessel disease (defined as \>50% angiographic stenosis in other vessels)
* Chronic total occlusion in the target artery
* Moderate to severe valvular disease
* Moderate to severe left ventricular impairment
* Chronotropic incompetence with a pacemaker
* Contraindication to PCI or a drug-eluting stents
* Contraindication to antiplatelet therapy
* Contraindication to adenosine
* Moderate to severe respiratory disease
* Physical inability to exercise
* Pregnant
* Inability to consent

Where it's running

  • Mid and South Essex NHS Foundation Trust
    Basildon, United Kingdom     Recruiting
  • Royal Bournemouth and Christchurch Hospitals NHS Foundation Trust
    Bournemouth, United Kingdom     Recruiting
  • Imperial College NHS Trust
    London, United Kingdom     Recruiting
  • Royal Free Hospital NHS Foundation Trust
    London, United Kingdom     Recruiting
  • St George's University Hospitals NHS Foundation Trust
    London, United Kingdom     Recruiting
  • Portsmouth Hospitals NHS Trust
    Portsmouth, United Kingdom     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.