OCT-guided stent optimization to shorten dual antiplatelet therapy for stable angina
Official title: Optical Coherence Tomography for Stent Optimization and Its Impact on Short-Duration Dual Antiplatelet Therapy: A Single-Center, Prospective, Exploratory Study
Run by Korea University Guro Hospital · NCT07198529 · Data updated 2026-11-12
It will test whether using OCT to optimize stent placement lets people with stable angina who get PCI safely use a shorter course of dual antiplatelet therapy.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 19 Years and up |
| Sex | All |
| Enrollment | 130 (estimated) |
| Sponsor | Korea University Guro Hospital Academic / other |
| Locations | 1 site (Seoul, Gurodong-ro, Guro-gu) |
| Status | Recruiting |
| Started | September 30, 2025 |
| Main results expected | September 2029 |
| Study ends | September 2029 |
| Registry record updated | December 17, 2025 |
| Trial ID | NCT07198529 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults (≥19 years) with stable angina undergoing PCI with a CoCr-everolimus drug-eluting stent who can tolerate OCT and provide informed consent.
✕Probably not a fit
Patients with acute coronary syndrome, lesions that prevent OCT or device delivery, contraindications to antiplatelet drugs, or prior stents in the target lesion are unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective, single-center, open-label pilot registry enrolling patients with stable angina who undergo PCI with a cobalt-chromium everolimus-eluting stent. All participants receive intravascular OCT imaging to guide stent optimization, with DAPT duration determined according to predefined OCT-based criteria and clinical factors. The study tracks ischemic events (including stent thrombosis) and bleeding outcomes during follow-up to determine safety and feasibility of a shortened DAPT strategy. Patients with acute coronary syndromes, technical barriers to OCT, or contraindications to antiplatelet therapy are excluded.
Why it matters
Potential benefit: If successful, this approach could allow some patients to stop dual antiplatelet therapy sooner, lowering their risk of bleeding without raising stent-related complications.
How similar studies have gone: Prior imaging studies and registry data have shown that OCT-guided optimization can improve stent results and suggested OCT criteria for safe implantation, but few clinical studies have directly tested OCT-guided shortening of DAPT.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients who undergo PCI using a cobalt-chromium everolimus-eluting stent (CoCr-EES) * Diagnosis of stable angina * Ability and willingness to provide written informed consent approved by the Institutional Review Board (IRB), and to comply with the study protocol and clinical follow-up schedule * Age ≥ 19 years Exclusion Criteria: * Patients diagnosed with acute coronary syndrome (ACS), including unstable angina or acute myocardial infarction * Contraindications to antiplatelet therapy or OCT imaging * Presence of lesions with severe stenosis, heavy calcification, or marked vessel tortuosity that prevent passage of a guidewire or catheter * Patients with previously implanted coronary stents in the target lesion
Where it's running
-
Cardiovascular Center, Department of Internal Medicine, Korea University Guro Hospital
Seoul, Gurodong-ro, Guro-gu, South Korea Recruiting
Study contacts
- Study coordinator: Soohyung Park, MD, PhD
- Email: shp503@naver.com
- Phone: +82-10-3105-3710
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.