Identifying blood biomarkers in patients with coronary syndrome
Identification of Innovative Circulating and Cellular Biomarkers in Subjects With Acute and Chronic Coronary Syndrome (PLAQUE Study)
Istituto Nazionale di Ricovero e Cura per Anziani · NCT06103357
This study is trying to find new blood markers in patients with coronary syndrome who are having angioplasty to better understand heart disease.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 20 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Istituto Nazionale di Ricovero e Cura per Anziani (other) |
| Locations | 1 site (Ancona) |
| Trial ID | NCT06103357 on ClinicalTrials.gov |
What this trial studies
This observational study aims to identify innovative biomarkers, particularly microRNAs, in the blood of patients undergoing angioplasty for coronary syndrome. It will enroll twenty patients with either acute coronary syndrome or chronic coronary syndrome who meet specific clinical criteria for the procedure. Blood samples will be collected before and after angioplasty from various sites, including upstream and downstream of the coronary lesion, to analyze microRNA expression and levels of inflammatory molecules. The study seeks to enhance understanding of the biological markers associated with coronary artery disease.
Who should consider this trial
Good fit: Ideal candidates include patients with acute coronary syndrome or chronic coronary syndrome who are clinically indicated for angioplasty.
Not a fit: Patients with contraindications to anticoagulant therapy or severe comorbidities may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic and therapeutic strategies for patients with coronary syndrome.
How similar studies have performed: Other studies have explored biomarkers in coronary syndrome, but this specific approach focusing on microRNAs is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Clinical indication for the PCI procedure according to the latest ESC (European Society of Cardiology) Guidelines * Coronary stenosis treated with angioplasty must be located in the proximal segments of the three main vessels: IVA, CX and CD * The vessels must have a diameter of their mid-distal section ≥ 3 mm * Patients with NSTEMI ACS and clinical indication with favorable anatomy for coronary angioplasty, also called percutaneous coronary intervention (PCI), (for the ACS group) * Patients with clinically incipient SCC with stable angina (or significant anginal equivalents) and clinical indication with favorable anatomy for PCI (for the SCC group) Exclusion Criteria: * Contraindications to anticoagulant/antiplatelet therapy * Extensive calcifications and/or tortuosity of the major epicardial segments * Evidence of thrombotic occupation * Patients with hemodynamic instability * Patients with EF (ejection fraction) \< 35% * Patients with severe chronic renal failure (e-GFR \< 30 mL/min)
Where this trial is running
Ancona
- IRCCS INRCA Hospital — Ancona, Italy (RECRUITING)
Study contacts
- Study coordinator: Anna Rita Bonfigli, PhD
- Email: a.bonfigli@inrca.it
- Phone: 0718003719
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Coronary Syndrome, Acute Coronary Syndrome, Chronic Coronary Syndrome, microRNAs, soluble ST2, interleukin-6