Identifying biomarkers to predict kidney injury in diabetic patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on patients with diabetes mellitus who are at risk of acute kidney injury during procedures involving contrast dye, such as percutaneous coronary interventions. The study aims to develop a biomarker panel that can predict the likelihood of contrast-induced nephropathy, which is a significant complication for these patients. By collecting serum and urine samples from participants, researchers will identify natural biomarkers that could enhance early detection and improve patient outcomes. The study will not involve any additional interventions beyond routine clinical care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age \> 18 years, known diabetes mellitus or BM on arrival consistent with probable diagnosis of diabetes, eGFR \<60 ml/min
2. Undergoing a PCI procedure
3. Agrees to the additional collection of blood and urine samples as outlined above
4. Agrees to access of their clinical records for the collection of relevant medical data
5. No history or signs of drug abuse
6. Able to understand and sign the written Informed Consent Form
7. Able and willing to follow the Protocol requirements

Exclusion Criteria:

1. Cardiogenic shock
2. Pregnancy
3. Patient on renal replacement therapy (haemodialysis/CAPD/renal transplant)
4. Known clinically significant infection such as HIV, Hepatitis or TB
5. Any patient determined not able to make a reasoned, informed consent prior to the planned interventional procedure

Where it's running

• The London Chest Hospital
  London, United Kingdom Recruiting

Study contacts

• Principal investigator: Akhil Kapur — Consultant Cardiologist and Honorary Senior Lecturer, Barts and the London Nhs Trust
• Study coordinator: Akhil Kapur
• Email: akhil.kapur@bartsandthelondon.nhs.uk
• Phone: 0208 983 2413

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Preventing lower limb artery disease in adults with diabetes using a risk-prediction model and HAPA-based nursing

  A risk-prediction model is tested in adults with type 2 diabetes to see if a nursing plan based on the HAPA model can reduce peripheral artery disease in the legs.

  Recruiting Second Affiliated Hospital of Nanchang University · Nanchang, Jang XI · NCT07881588

• Rilzabrutinib in adults with severe kidney impairment vs. normal kidney function

  This study tests how rilzabrutinib behaves in the body and its safety in adults with severe kidney impairment compared to healthy adults.

  Recruiting Phase 1 Sanofi · Hialeah, Florida · NCT07853131

• DiaFootCare: a mobile app to help adults with diabetic foot ulcers manage self-care in Oman

  A mobile app called DiaFootCare will be tested to see if it helps adults with diabetic foot ulcers in Oman take better care of themselves and improve healing compared with usual care.

  Recruiting Oman Ministry of Health · Muscat · NCT07815275

• Predictive CGM with App for people with type 1 or insulin-treated type 2 diabetes

  This study tests whether using the Accu-Chek SmartGuide CGM with its Predict App can reduce fear of hypoglycemia and improve related behaviors and confidence in adults with type 1 or insulin-treated type 2 diabetes.

  Recruiting Fidam Rdc · Bad Mergentheim, Baden-Wurttemberg · NCT07814508

• SugarVita 2.0: a 12-week digital game for adults with type 2 diabetes

  This 12-week pilot tests SugarVita 2.0, a serious digital game, to see if it helps adults with type 2 diabetes manage their condition and feel more confident.

  Recruiting Maxima Medical Center · Eindhoven, North Brabant · NCT07812623

• Linking social care with healthcare to help manage chronic diseases

  This trial tests whether pairing patients with trained community health workers can help them get transportation, healthy food, information, and better access to care to improve health in conditions like hypertension, diabetes, and high cholesterol.

  Recruiting at 2 sites University of Arizona · Tucson, Arizona and 1 other locations · NCT07799961

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.