Identifying biomarkers for vascular anomalies
Identification of Biomarkers for Patients with Vascular Anomalies
This study is trying to find simple blood tests that can help doctors better diagnose and treat patients with rare blood vessel problems like Generalized Lymphatic Anomaly and Gorham-Stout Disease.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1000 (estimated) |
| Ages | 1 Day and up |
| Sex | All |
| Sponsor | Children's Hospital Medical Center, Cincinnati Academic / other |
| Locations | 2 sites (Boston, Massachusetts and 1 other locations) |
| Trial ID | NCT03001180 on ClinicalTrials.gov |
What this trial studies
This observational study aims to identify non-invasive blood biomarkers for patients with various vascular anomalies, including Generalized Lymphatic Anomaly and Gorham-Stout Disease. Participants undergoing surgical procedures or sclerotherapy will have blood and tissue samples collected to analyze angiogenic factors and understand disease-causing pathways. The goal is to improve diagnosis and treatment options for these rare and potentially life-threatening conditions by avoiding invasive tissue biopsies.
Who should consider this trial
Good fit: Ideal candidates include patients undergoing surgical resection or sclerotherapy for vascular anomalies who consent to participate.
Not a fit: Patients who do not have vascular anomalies or are not undergoing the specified procedures may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better diagnostic tools and targeted therapies for patients with vascular anomalies.
How similar studies have performed: While vascular anomalies are rare, similar studies focusing on biomarker identification in other conditions have shown promise, suggesting potential for success in this novel approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Any patient having labs drawn as standard of care will have blood drawn for the study if consented/ assented. * All patients who are undergoing a surgical procedure or sclerotherapy are currently consented for participation in the tissue bank. Exclusion Criteria: * N/A
Where this trial is running
Boston, Massachusetts and 1 other locations
- Boston Children's Hospital — Boston, Massachusetts, United States (Terminated)
- Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States (Recruiting)
Study contacts
- Principal investigator: Timothy LeCras, PhD — Children's Hospital Medical Center, Cincinnati
- Study coordinator: Timothy LeCras, PhD
- Email: hvmcresearch@cchmc.org
- Phone: 5138034862
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.