Identifying biomarkers for chronic musculoskeletal pain
Diagnostic and Prognostic Biomarkers for High-impact Chronic Pain: Development and Validation
This study is trying to find specific markers in the body that can help tell if adults with chronic musculoskeletal pain will recover or continue to experience severe pain, so that better, personalized treatments can be developed.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 250 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Stanford University Academic / other |
| Locations | 1 site (Palo Alto, California) |
| Trial ID | NCT04994249 on ClinicalTrials.gov |
What this trial studies
This study aims to discover and validate diagnostic and prognostic biomarkers that can differentiate between recovery and persistent high-impact chronic pain in adults suffering from chronic musculoskeletal pain. Given the significant public health crisis posed by chronic pain, which affects millions of Americans, the research focuses on understanding the factors that contribute to the severity and trajectory of pain. By identifying these biomarkers, the study seeks to develop more effective, personalized treatment strategies for patients who are resistant to current pain management options.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18-80 who are experiencing chronic musculoskeletal pain as defined by the World Health Organization.
Not a fit: Patients with chronic musculoskeletal pain due to inflammatory diseases or those with significant cognitive impairments may not benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment strategies for patients suffering from high-impact chronic pain.
How similar studies have performed: Other studies have shown promise in identifying biomarkers for chronic pain, but this specific approach focusing on high-impact chronic pain is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 1) Inclusion criteria: Adults (18-80 years; \~64% female expected based on clinic distribution) with chronic MSP as categorized by the World Health Organization (WHO). Exclusion Criteria: * 1) Chronic musculoskeletal pain (MSP) explained by inflammatory disease (e.g., rheumatoid arthritis, lupus) or CP with a primary diagnosis other than chronic MSP (e.g., neuropathic pain), (2) significant cognitive impairment, (3) MRI contraindication, (4) medical or psychiatric problems interfering with the study, (5) current medicolegal factors (e.g., open disability claim), (6) plans for surgery during the study, (7) pregnancy and (8) Children under the age of 18 will not be included in the study.
Where this trial is running
Palo Alto, California
- Stanford University — Palo Alto, California, United States (Recruiting)
Study contacts
- Principal investigator: Sean Mackey, MD, PhD. — Stanford University
- Study coordinator: Anne Cunniffe Marcy, MSBH
- Email: acmarcy@stanford.edu
- Phone: 6507216931
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.