Identifying biomarkers for chronic inflammation and aging in infertile men
Definition of a Personalized Signature of Chronic Inflammation and Early Aging Predictive of the Development of Comorbidities in Infertile Men
This study is trying to find new health markers in infertile men to see how chronic inflammation and aging affect their overall health and help prevent other health issues.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 350 (estimated) |
| Ages | 18 Years to 50 Years |
| Sex | Male |
| Sponsor | IRCCS San Raffaele Academic / other |
| Locations | 1 site (Milan, Lombardy) |
| Trial ID | NCT06082362 on ClinicalTrials.gov |
What this trial studies
This observational study aims to identify new biomarkers and prognostic factors that can help develop personalized strategies to prevent comorbidities in infertile men. It focuses on understanding the link between male infertility and overall health, particularly the increased risk of both oncologic and non-oncologic conditions. By collecting clinical and biological materials, the study seeks to explore the associations between chronic inflammation, aging, and infertility. The findings could provide insights into the health status of infertile men and inform future preventive measures.
Who should consider this trial
Good fit: Ideal candidates for this study are men aged 18 to 50 with a diagnosis of oligoasthenoteratozoospermia (OAT) or idiopathic non-obstructive azoospermia (iNOA).
Not a fit: Patients with secondary infertility, a history of hematological diseases, or those who have been treated with antibiotics in the six months prior to enrollment may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to personalized prevention strategies for comorbidities in infertile men, improving their overall health outcomes.
How similar studies have performed: While there is emerging evidence linking male infertility to increased health risks, this study's specific approach to identifying biomarkers is novel and has not been extensively tested in previous studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \> 18 and \< 50 years; * White race * Men with OAT o iNOA infertility diagnosis * ability to sign the consent information Exclusion Criteria: * inability to sign the consent information * secondary infertility diagnosis * history of hematological diseases * people treated with antibiotics in the six months prior the enrollment
Where this trial is running
Milan, Lombardy
- IRCCS Ospedale San Raffaele — Milan, Lombardy, Italy (Recruiting)
Study contacts
- Principal investigator: Andrea Salonia, MD — IRCCS Ospedale San Raffaele
- Study coordinator: Andrea Salonia, MD
- Email: salonia.andrea@hsr.it
- Phone: 02 2643 5661
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.