Clinical trial Recruiting at 49 sites Interventional Ages 18 and up

Hypertension Care Expansion in Nigeria 2.0

Official title: Hypertension Treatment in Nigeria Program 2.0

Run by Washington University School of Medicine · NCT07351162 · Data updated 2026-11-12

This program tests a modified WHO HEARTS hypertension treatment bundle in adults with high blood pressure across five new Nigerian states to see if blood pressure can be better controlled.

More Hypertension (HTN) trials

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment10000 (estimated)
SponsorWashington University School of Medicine
Academic / other
Locations49 sites (Mbalano, Abia State and 48 other locations)
StatusRecruiting
StartedFebruary 2, 2026
Main results expectedJanuary 31, 2029
Study endsJanuary 31, 2030
Registry record updatedOctober 14, 2026
Trial IDNCT07351162 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 18 and older with elevated blood pressure or a history of hypertension, including pregnant or cognitively impaired adults, in the specified Nigerian PHCs.

Probably not a fit

Patients without elevated blood pressure or not receiving care at the participating PHCs may not experience direct benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

HTN 2.0 builds on the prior HTN program by expanding the HEARTS bundle to Abia, Delta, Gombe, Jigawa, and Oyo, while checking whether hypertension control is sustained in the capital. The intervention uses a standardized package for hypertension care at primary health centers, adapted for the local context. Eligible participants include adults with elevated blood pressure, those already on BP-lowering meds, pregnant women, and adults with cognitive impairment. Exclusions cover individuals under 18 and detained persons. Lead sponsorship comes from Washington University School of Medicine, with collaboration from Nigerian partners and NHLBI, at select PHCs in Abia State.

Why it matters

Potential benefit: If successful, the program could improve blood pressure control for adults in multiple Nigerian states and sustain gains from the original HTN program.

How similar studies have gone: Previous HTN program in Nigeria demonstrated improved treatment and control using the HEARTS package, supporting potential benefit for HTN 2.0.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Adults (≥18 years old),
* Elevated blood pressure (SBP ≥ 140 mmHg or DBP ≥ 90 mmHg) documented or measured by a health care professional (e.g., physician, community health extension worker, or community health officer) on two separate occasions or taking a BP-lowering medication, or a history of hypertension.
* Pregnant women are eligible for this program, or
* Cognitively impaired adults are eligible for this program..

Exclusion Criteria:

This program will not include any of the following special populations:

* Individuals who are not yet adults (minors): i.e. infants, children, or teenagers \<18 years old, or
* Prisoners or other detained individuals.

Where it's running

  • Amiyi Uhu PHC
    Mbalano, Abia State, Nigeria
    Recruiting
  • Mbagwu PHC
    Mbalano, Abia State, Nigeria
    Recruiting
  • Nunya Health Centre
    Mbalano, Abia State, Nigeria
    Recruiting
  • Nvurunvu PHC
    Mbalano, Abia State, Nigeria
    Recruiting
  • Onuaku PHC
    Mbalano, Abia State, Nigeria
    Recruiting
  • Amaeke PHC
    Umuahia, Abia State, Nigeria
    Recruiting
Show 43 more locations
  • Isiama Afara PHC
    Umuahia, Abia State, Nigeria
    Recruiting
  • Oriendu PHC
    Umuahia, Abia State, Nigeria
    Recruiting
  • Umuda Isingwu PHC
    Umuahia, Abia State, Nigeria
    Recruiting
  • Umukabia PHC
    Umuahia, Abia State, Nigeria
    Recruiting
  • Igun PHC
    Eku, Delta, Nigeria
    Recruiting
  • Okpara Waterside PHC
    Eku, Delta, Nigeria
    Recruiting
  • Orhondo-Eku PHC
    Eku, Delta, Nigeria
    Recruiting
  • Edjemuyavwe PHC
    Oghara, Delta, Nigeria
    Recruiting
  • Jesse PHC
    Oghara, Delta, Nigeria
    Recruiting
  • Oghareki PHC
    Oghara, Delta, Nigeria
    Recruiting
  • Amukpe PHC
    Sapele, Delta, Nigeria
    Recruiting
  • Gana PHC
    Sapele, Delta, Nigeria
    Recruiting
  • Urban PHC
    Sapele, Delta, Nigeria
    Recruiting
  • Abuja PHC
    Gadam, Gombe State, Nigeria
    Recruiting
  • Gadam PHC
    Gadam, Gombe State, Nigeria
    Recruiting
  • Kumbiya Kumbiya PHC
    Gombe, Gombe State, Nigeria
    Recruiting
  • Madaki PHC
    Gombe, Gombe State, Nigeria
    Recruiting
  • Nassarawo PHC
    Gombe, Gombe State, Nigeria
    Recruiting
  • Pantami PHC
    Gombe, Gombe State, Nigeria
    Recruiting
  • Town PHC
    Gombe, Gombe State, Nigeria
    Recruiting
  • Tudun Wada PHC
    Gombe, Gombe State, Nigeria
    Recruiting
  • Bogo PHC
    Kumo, Gombe State, Nigeria
    Recruiting
  • Kumo PHC
    Kumo, Gombe State, Nigeria
    Recruiting
  • Bamaina PHC
    Birnin Kudu, Jigawa State, Nigeria
    Recruiting
  • Magajin Gari PHC
    Birnin Kudu, Jigawa State, Nigeria
    Recruiting
  • Sudumina PHC
    Birnin Kudu, Jigawa State, Nigeria
    Recruiting
  • Kachi PHC
    Dutse, Jigawa State, Nigeria
    Recruiting
  • Kudai PHC
    Dutse, Jigawa State, Nigeria
    Recruiting
  • Sakwaya PHC
    Dutse, Jigawa State, Nigeria
    Recruiting
  • Andaza PHC
    Kiyawa, Jigawa State, Nigeria
    Recruiting
  • Katanga PHC
    Kiyawa, Jigawa State, Nigeria
    Recruiting
  • Kiyawa PHC
    Kiyawa, Jigawa State, Nigeria
    Recruiting
  • Ogharefe PHC
    Oghara, Ogharefe, Nigeria
    Recruiting
  • Ojoo PHC
    Akinyele, Oyo State, Nigeria
    Recruiting
  • Alakia Model PHC
    Egbeda, Oyo State, Nigeria
    Recruiting
  • Alegongo PHC
    Ibadan, Oyo State, Nigeria
    Recruiting
  • Apete PHC
    Ibadan, Oyo State, Nigeria
    Recruiting
  • Idi Ogungun PHC
    Ibadan, Oyo State, Nigeria
    Recruiting
  • Iwo Road PHC
    Ibadan, Oyo State, Nigeria
    Recruiting
  • Odo-Ona Elewe PHC
    Ibadan, Oyo State, Nigeria
    Recruiting
  • Oke Bola PHC
    Ibadan, Oyo State, Nigeria
    Recruiting
  • Oniyanrin PHC
    Ibadan, Oyo State, Nigeria
    Recruiting
  • Oranyan PHC
    Ibadan, Oyo State, Nigeria
    Recruiting

Study contacts

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.