Hyaluronic Acid and i-PRF Injection After Arthrocentesis for TMJ Disc Displacement
Official title: Evaluation of Hyaluronic Acid and I-PRF Mixture for Intra-articular Injection Following Arthrocentesis in The Management of TMJ Reducible Disc Displacement: A Four Arm Comparative Trial
Run by Mansoura University · NCT07683650 · Data updated 2026-11-12
This trial tests whether injecting a mix of hyaluronic acid with i-PRF after arthrocentesis helps people with TMJ disc displacement with reduction.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | All |
| Enrollment | 72 (estimated) |
| Sponsor | Mansoura University Academic / other |
| Locations | 1 site (Al Mansurah) |
| Status | Recruiting |
| Started | January 6, 2026 |
| Main results expected | December 2026 |
| Study ends | February 2027 |
| Registry record updated | July 14, 2026 |
| Trial ID | NCT07683650 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 to 45 with reducible TMJ disc displacement requiring arthrocentesis and willing to participate in a six-month follow-up.
✕Probably not a fit
Patients with non-reducible disc displacement, prior TMJ interventions, systemic inflammatory or autoimmune conditions, or contraindications to intra-articular injections may not experience benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This four-arm randomized trial compares arthrocentesis alone, arthrocentesis with hyaluronic acid, arthrocentesis with hyaluronic acid plus betamethasone, and arthrocentesis with hyaluronic acid plus injectable platelet-rich fibrin (i-PRF) in adults with reducible TMJ disc displacement. All participants receive standard joint lavage, and outcomes are tracked for six months, focusing on pain, mouth opening, jaw movement, and joint clicking. The aim is to determine which intra-articular treatment provides the best relief and functional restoration. Primary data will come from changes in pain-free mouth opening and subjective pain, with secondary measures including lateral/protrusive movements and clicking presence.
Why it matters
Potential benefit: If successful, the HA + i-PRF combination could improve pain, function, and jaw mobility for patients with TMJ disc displacement.
How similar studies have gone: Prior studies have shown potential benefits of HA and biologic additives in TMJ interventions, but this specific HA + i-PRF after arthrocentesis approach is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age: 18 - 45 years. 2. Patients with disc displacement with reduction in any of the TMJs. 3. arthralgia. 4. Limited unassisted mouth opening. 5. Co-operative patients. Exclusion Criteria: 1. Patients with previous history of TMJ minimally invasive interventions. 2. Patients with autoimmune or connective tissue diseases affecting the joints. 3. Patients with neurological disorders. 4. Patients with a history of condylar fractures or ankylosis. 5. Patients with psychological problems. 6. Patients receiving non-steroidal anti-inflammatory drugs within 48 hours preoperatively, or systemic use of corticosteroids within 2 weeks. 7. Patients on anticoagulants, suffering from platelet function disorders or fibrinogen deficiency. 8. Patients with moderate to severe myogenic pain.
Where it's running
-
Faculty of Dentistry Mansoura University
Al Mansurah, Egypt Recruiting
Study contacts
- Principal investigator: Nada Hamed — Faculty of Dentistry Mansoura University
- Study coordinator: Nada Hamed
- Email: hamednada99@mans.edu.eg
- Phone: 00201119659235
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.