How your daily body clock relates to breathing, activity, and nutrition after COVID-19

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a cross-sectional observational study enrolling adults aged 18–65 with confirmed post-COVID-19 syndrome to compare respiratory muscle strength, physical activity, nutritional habits, sleep quality, fatigue, and gastrointestinal symptoms across chronotypes (morning, intermediate, evening) defined by the Munich Chronotype Questionnaire. Respiratory function will be measured with maximal inspiratory/expiratory pressures (MIP/MEP), dynamic testing using a POWERbreathe device, and respiratory endurance threshold protocols, while activity and nutrition are captured with validated questionnaires such as the IPAQ. The protocol also includes genetic analysis of CLOCK gene polymorphisms to provide an objective correlate of circadian differences. All testing is performed in person at a single center and participants must be clinically stable and able to complete the assessments.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosed with Post-COVID-19 Syndrome
* Aged between 18-65 years
* Able to read and understand Turkish
* Voluntary participation
* Classified as Post-Covid Functional Status Scale (PCFS) grade 2-3
* Clinically stable condition
* No uncontrolled comorbidities (e.g., hypertension, diabetes under control)
* No orthopedic or neurological conditions affecting exercise testing

Exclusion Criteria:

* Recent myocardial infarction or pulmonary embolism
* Severe uncontrolled chronic diseases
* Neurological or orthopedic conditions limiting mobility
* Psychiatric or neurological disorders affecting cooperation or test compliance
* Inability to complete assessments

Where it's running

• Hacettepe University Faculty of Physical Therapy and Rehabilitation
  Ankara, Altindağ, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Ebru Çalık, Professor
• Email: ecalik85@gmail.com
• Phone: +905442850087

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.