How thyroid problems affect liver blood tests

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center observational study at Sohag University Hospital will compare liver function tests among adults aged 20–60 who have hypothyroidism or hyperthyroidism (treated and controlled, treated but uncontrolled, or newly diagnosed) and healthy euthyroid controls. Participants will undergo clinical assessment and blood sampling to measure standard liver function parameters, with exclusions for known liver disease, pregnancy or lactation, severe infection, heart disease, or medications that affect liver function. No experimental treatments are given; the study analyzes disease status and laboratory results to identify patterns and associations. The goal is to clarify how different thyroid states correlate with common liver test abnormalities.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* All patients between the ages of 20-60 years old either with Hypothyroidism or Hyperthyroidism (controlled on treatment or not) and firstly diagnosed Hypothyroidism or Hyperthyroidism.
* Euthyroid controls (clinically healthy control subjects were recruited from the general population with the same socio-economic status with the subjects.)

Exclusion Criteria:

* Patients aged \< 20 years old.
* Patients With Liver Disease.
* Pregnant and lactating women.
* Patients with severe infections or sepsis.
* Patients with Heart Disease.
* Patients who on drugs that can affect liver function such as phenothiazine, phenylbutazone, methyldopa, among others.

Where it's running

• Sohag University Hospital
  Sohag, Egypt Recruiting

Study contacts

• Study coordinator: Omnia A Mohamed, Resident
• Email: omnia_ahmed_post@med.sohag.edu.eg
• Phone: 01285252564

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.