How thyroid problems affect liver blood tests
Impact Of Thyroid Dysfunction on Liver Function Tests In Sohag University Hospital
This observational study will see if adults aged 20–60 with treated, untreated, or newly diagnosed hypo- or hyperthyroidism have different liver blood test results compared with healthy euthyroid controls.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 20 Years to 60 Years |
| Sex | All |
| Sponsor | Sohag University Academic / other |
| Locations | 1 site (Sohag) |
| Trial ID | NCT07354048 on ClinicalTrials.gov |
What this trial studies
This single-center observational study at Sohag University Hospital will compare liver function tests among adults aged 20–60 who have hypothyroidism or hyperthyroidism (treated and controlled, treated but uncontrolled, or newly diagnosed) and healthy euthyroid controls. Participants will undergo clinical assessment and blood sampling to measure standard liver function parameters, with exclusions for known liver disease, pregnancy or lactation, severe infection, heart disease, or medications that affect liver function. No experimental treatments are given; the study analyzes disease status and laboratory results to identify patterns and associations. The goal is to clarify how different thyroid states correlate with common liver test abnormalities.
Who should consider this trial
Good fit: Adults aged 20–60 with hypothyroidism or hyperthyroidism (including treated/controlled, treated/uncontrolled, and newly diagnosed cases) or healthy euthyroid adults without liver disease, pregnancy, severe infection, heart disease, or use of medications that affect liver function.
Not a fit: Children under 20, adults outside the 20–60 age range, people with known liver disease, pregnant or lactating women, those with severe infections or heart disease, or anyone taking drugs that affect liver function are unlikely to be eligible or to benefit from the study's findings.
Why it matters
Potential benefit: If successful, results could help doctors interpret abnormal liver tests in people with thyroid dysfunction and reduce unnecessary liver workups.
How similar studies have performed: Previous observational studies have reported associations between thyroid dysfunction and abnormal liver function tests, so this study builds on an established but still-evolving evidence base.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All patients between the ages of 20-60 years old either with Hypothyroidism or Hyperthyroidism (controlled on treatment or not) and firstly diagnosed Hypothyroidism or Hyperthyroidism. * Euthyroid controls (clinically healthy control subjects were recruited from the general population with the same socio-economic status with the subjects.) Exclusion Criteria: * Patients aged \< 20 years old. * Patients With Liver Disease. * Pregnant and lactating women. * Patients with severe infections or sepsis. * Patients with Heart Disease. * Patients who on drugs that can affect liver function such as phenothiazine, phenylbutazone, methyldopa, among others.
Where this trial is running
Sohag
- Sohag University Hospital — Sohag, Egypt (Recruiting)
Study contacts
- Study coordinator: Omnia A Mohamed, Resident
- Email: omnia_ahmed_post@med.sohag.edu.eg
- Phone: 01285252564
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.