Right blood level of ciprofol for anesthesia during thyroid surgery
Official title: Median Effective Concentration of Ciprofol and Its Correlation With Bispectral Index: A Prospective Observational Study
Run by Peking University Shenzhen Hospital · NCT07294989 · Data updated 2026-11-12
This test looks at ciprofol blood levels to see what keeps adults aged 18–65 safely unconscious during elective thyroidectomy.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 101 (estimated) |
| Sponsor | Peking University Shenzhen Hospital Academic / other |
| Locations | 1 site (Shenzhen, Guangdong) |
| Status | Recruiting |
| Started | July 1, 2025 |
| Main results expected | June 30, 2026 |
| Study ends | June 30, 2026 |
| Registry record updated | January 6, 2026 |
| Trial ID | NCT07294989 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–65 with ASA physical status I–II who are scheduled for elective thyroidectomy and can give written informed consent are the intended participants.
✕Probably not a fit
Patients with severe liver or kidney failure, significant cardiovascular disease, extreme BMI, recent sedative/opioid use, known hypersensitivity to propofol/ciprofol, or major neuropsychiatric disorders are unlikely to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This single-center observational study enrolls adults scheduled for elective thyroidectomy who meet ASA I–II criteria. General anesthesia is induced with ciprofol for all participants while consciousness levels are measured using standardized scales during induction. Investigators record ciprofol blood concentrations and follow patients after surgery to track pain and cognitive recovery. The goal is to relate blood levels to clinical depth of anesthesia and short-term postoperative outcomes.
Why it matters
Potential benefit: If successful, the findings could help clinicians choose safer, more effective ciprofol dosing for thyroid surgery, potentially speeding recovery and reducing side effects.
How similar studies have gone: Previous clinical work with ciprofol for general anesthesia has shown promising sedation comparable to propofol, but precise target blood concentrations for thyroidectomy remain limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged 18-65 years * Scheduled for elective thyroidectomy * ASA physical status classification I-II * Willing to participate and providing written informed consent Exclusion Criteria: * Recent use of sedatives or opioid analgesics * Severe hepatic or renal dysfunction defined as:Child-Pugh class C (score ≥10), Creatinine clearance \<35 mL/min ,Requiring preoperative dialysis * Significant cardiovascular comorbidities * Body mass index ≥35 kg/m² or \<18.5 kg/m² * Known hypersensitivity or adverse reactions to propofol/ciprofol * Neuropsychiatric disorders including:Alzheimer's disease,History of cerebrovascular events,Traumatic brain injury,Space-occupying brain lesions,Other significant neurological deficits
Where it's running
-
Peking University Shenzhen Hospital
Shenzhen, Guangdong, China Recruiting
Study contacts
- Study coordinator: Tao Luo
- Email: 496855048@qq.com
- Phone: +86 135 1082 0779
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.