How Propofol and Sevoflurane Affect miRNA in Living Kidney Donors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In living donor kidney surgery, tissue damage triggers inflammatory and stress responses. The study compares two anesthesia maintenance methods—sevoflurane and propofol—to see how they influence circulating microRNAs involved in inflammation and immune regulation. Participants are adults aged 18–65 with ASA I–II status undergoing elective donor nephrectomy, randomized 1:1 to the two anesthesia approaches. The trial uses blinded allocation concealment and collects samples pre-, intra-, and post-operatively to analyze miR-146a and miR-155 dynamics, among others. The study is conducted at Gaziantep University and aims to understand whether anesthetic choice can modulate perioperative molecular responses relevant to donor physiology and transplant outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Living kidney donors aged between 18 and 65 years.
* Scheduled for an elective donor nephrectomy operation under general anesthesia.
* American Society of Anesthesiologists (ASA) physical status I or II.
* Body Mass Index (BMI) strictly less than 35 kg/m².
* Provided written informed voluntary consent to participate in the study.

Exclusion Criteria:

* Known history or clinical diagnosis of malignancy or Diabetes Mellitus (DM).
* Active or history of chronic systemic inflammatory or autoimmune diseases.
* Chronic use of analgesics or documented history of substance abuse.
* Known hypersensitivity or allergic reaction to any of the anesthetic agents used in the study (Sevoflurane or Propofol).
* Diagnosed with dementia, severe cognitive impairment, or any significant psychiatric disorder.

Where it's running

• Gaziantep University Sahinbey Research and Application Hospital
  Gaziantep, Sahinbey, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Elife SEVİLİR, Medical Doctor
• Email: esev1234@gmail.com
• Phone: +905423794800

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.