How organs communicate during a heart attack
Official title: Systemic Organ Communication in STEMI
Run by Heinrich-Heine University, Duesseldorf · NCT03539133 · Data updated 2026-11-12
We will collect clinical data from adults with STEMI to see how different organs respond during and after a heart attack.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 1000 (estimated) |
| Sponsor | Heinrich-Heine University, Duesseldorf Academic / other |
| Locations | 1 site (Düsseldorf) |
| Status | Recruiting |
| Started | October 18, 2017 |
| Main results expected | June 2030 |
| Study ends | June 2030 |
| Registry record updated | January 22, 2026 |
| Trial ID | NCT03539133 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 or older with a confirmed ST-segment elevation myocardial infarction who can give informed consent are the intended participants.
✕Probably not a fit
People under 18, individuals without STEMI, or patients too unstable or unable to consent are not eligible and unlikely to benefit from enrollment.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This open-ended, prospective observational cohort will enroll adults presenting with ST-segment elevation myocardial infarction (STEMI) and systematically collect clinical data. Data collection will focus on routine clinical measures obtained during hospital care and follow-up, such as vital signs, laboratory results, imaging reports, and treatment timelines. The aim is to identify system-level signals or "master switches" that connect myocardial ischemia with responses in other organs and common comorbidities. No experimental treatments are administered as part of the protocol; analyses are observational and intended to generate hypotheses for future work.
Why it matters
Potential benefit: If successful, the findings could reveal biomarkers or patterns that improve risk prediction and help tailor care after STEMI.
How similar studies have gone: Other observational cohorts of myocardial infarction have identified biomarkers and systemic responses, so this approach has produced useful insights even if it has not yet led to major new therapies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients suffering from STEMI Exclusion Criteria: * \< 18 years
Where it's running
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Division of Cardiology, Pulmonary Disease and Vascular Medicine
Düsseldorf, Germany Recruiting
Study contacts
- Principal investigator: Christian Jung, MD, PhD — Division of Cardiology, Pulmonary Disease and Vascular Medicine
- Study coordinator: Christian Jung, MD, PhD
- Email: christian.jung@med.uni-duesseldorf.de
- Phone: +492118118800
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Adenosine given before primary PCI to reduce no-reflow in STEMI patients.
See if giving intracoronary adenosine before primary PCI lowers the chance of slow flow/no-reflow in adults with STEMI.
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Using cardiac MRI and AI to predict outcomes after STEMI
This project will try to use routine cardiac MRI scans plus AI to see if imaging features can predict long-term outcomes in people who had a STEMI treated with primary PCI.
-
Using beta-blockers for heart attack patients in intensive care
This study is testing if the heart medication metoprolol can help heart attack patients in intensive care feel better and avoid worsening their condition.
-
Using an aspiration catheter for treating heart attacks
This study tests whether using a special catheter can help remove blood clots from the heart arteries during a heart attack to improve blood flow and patient recovery.
-
Using machine learning to improve early diagnosis of acute cardiovascular conditions
This study is testing a new tool that uses advanced computer technology to help doctors quickly and accurately diagnose serious heart problems in patients who come to the emergency room with chest pain or trouble breathing.
-
Administering adrenaline in STEMI patients during PCI to prevent no reflow
This study tests if giving adrenaline during heart procedures can help STEMI patients avoid complications with blood flow without causing heart rhythm problems.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.