How movement and nervous system function relate after stroke
Official title: SOMADC-CC (SOMAtic Dysfunction Characterization Following Chronic Cerebrovascular Disease): Biomarker Study
Run by University of California, Davis · NCT07737873 · Data updated 2026-11-12
This study tests whether measures of movement efficiency and nerve function relate to outcomes in adults who had a stroke.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | University of California, Davis Academic / other |
| Locations | 1 site (Sacramento, California) |
| Status | Recruiting |
| Started | July 1, 2026 |
| Main results expected | June 30, 2028 |
| Study ends | June 30, 2028 |
| Registry record updated | July 30, 2026 |
| Trial ID | NCT07737873 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18 and older with a history of ischemic stroke, able to sit, lie in various positions, and walk independently with or without aids, who can consent or have an LAR.
✕Probably not a fit
Individuals unlikely to benefit may include those unable to participate in the required assessments or who do not experience measurable changes in the studied parameters.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study examines connections between musculoskeletal function, movement efficiency, and nervous system function in people who had a stroke. Researchers use a novel osteopathic examination approach called the Functional Pathology of the Musculoskeletal System (FPMSS) to quantify somatic dysfunction. The study builds on prior work suggesting early changes after ischemic stroke, and aims to see how these factors correlate with patient-reported outcomes and quality of life. Participants are adults with a prior stroke, recruited from UC Davis Stroke Clinic, who can sit, stand, and walk with or without aids. Data collection includes clinical exams and surveys delivered via SMS or email.
Why it matters
Potential benefit: If the approach proves informative, it could improve understanding of post-stroke disability and guide personalized care strategies.
How similar studies have gone: Previous work suggests that somatic dysfunction can be quantified and may relate to neurological status, but this specific approach in chronic stroke is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria:
* • UC Davis Stroke Clinic outpatient patients \>3 months from previous stroke
* Adults ≥18 years
* Previous admission diagnosis or referral indication:
o Ischemic stroke (prior history of)
* Able to sit upright, lie supine, and lie lateral recumbent left/right positions
* Must be able to walk independently with/without walking aids.
* Participants must have the capacity to consent to study participation themselves or have a Legally Authorized Representative (LAR) available.
* Willingness to receive SMS (text) messages and/or email to complete REDCap QoL survey
Exclusion Criteria:
* • Acute skeletal fracture or known dislocation; history of pathologic (osteoporotic or neoplastic) skeletal fracture of thoracic cage, hip/pelvis/sacrum, or vertebral column
* Spinal column support brace (e.g. cervical collar)
* History of spinal cord injury with residual neuromuscular or sensory disability
* Clinical condition that would interfere with execution of movement or palpatory diagnostic testing, e.g. prohibitive chronic pain
* Participants who have received either OMT or chiropractic manipulation following their stroke and prior to enrollment.
Where it's running
-
University of California Davis
Sacramento, California, United States Recruiting
Study contacts
- Principal investigator: Alan Yee, D.O. — University of California, Davis
- Study coordinator: Alan Yee, D.O.
- Email: ahyee@ucdavis.edu
- Phone: 916-734-3588
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Deep phenotyping to explore recovery in young adults after stroke
This project will test whether a detailed health and sample-collection approach (deep phenotyping) is practical and acceptable for people aged 18–55 who have had a stroke.
-
Stem cell therapy for chronic stroke recovery
This study is testing whether using a patient's own stem cells can help people with long-term stroke recovery feel better and improve their daily functioning.
-
AI-based tools to help diagnose, treat and predict stroke outcomes across multiple hospitals
This study tests AI-powered tools on real-world stroke patients to see if they can improve pre-hospital triage, diagnosis, and outcome prediction while data stay securely within each hospital.
-
Web-based therapy using action observation and mirror therapy for arm weakness after stroke
This trial tests whether a mobile telerehabilitation app delivering action observation therapy (AOT) alone or combined AOT with mirror therapy (AOT-MT) can improve upper limb function in people with subacute stroke.
-
Remote Ischaemic Conditioning for Fatigue After Stroke 2
Aat least 12 weeks after stroke, adults with post-stroke fatigue will try a simple hand-arm cuff treatment at home to see if it helps reduce fatigue.
-
Dual-task balance training plus computer-based cognitive training after stroke
In adults who recently had a stroke, the study tests whether adding computerized cognitive exercises to balance training improves balance and other recovery outcomes.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.