How Fat Tissue May Create Endocannabinoids as Obesity and Diabetes Build Up
Official title: A Basic Study Using Human Abdominal Adipose Tissue Biopsies to Characterize the Role of Endocannabinoids in Adipocyte Differentiation
Run by Centre Hospitalier Universitaire Dijon · NCT07567287 · Data updated 2026-11-12
Researchers collect abdominal fat samples to see if the endocannabinoid system in fat cells contributes to obesity and type 2 diabetes.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Centre Hospitalier Universitaire Dijon Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Dijon) |
| Status | Recruiting |
| Started | September 3, 2026 |
| Main results expected | September 2028 |
| Study ends | September 2028 |
| Registry record updated | September 11, 2026 |
| Trial ID | NCT07567287 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults 18-80 undergoing abdominal surgery, including non-diabetic obese individuals and obese individuals with type 2 diabetes, across both sexes and postmenopausal status.
✕Probably not a fit
Participants will not receive a therapeutic treatment through this study; some may not experience direct personal benefit beyond contributing to scientific knowledge.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The study collects adipose tissue biopsies to explore how endocannabinoids produced in fat tissue relate to adipocyte differentiation. It leverages human samples from adults undergoing abdominal surgery, including non-diabetic obese and obese individuals with type 2 diabetes, to examine endocannabinoid signaling in adipose tissue. The project uses a collection-only design focused on tissue analysis without a therapeutic intervention. Results may help clarify tissue-level mechanisms behind energy storage and could inform future treatments targeting fat biology.
Why it matters
Potential benefit: If successful, the study could advance understanding of fat tissue biology and the endocannabinoid system, potentially guiding new approaches for obesity and diabetes management.
How similar studies have gone: Prior research supports a link between adipose endocannabinoid signaling and energy storage, but direct human biopsy-based characterization is relatively novel in this specific context.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Control group : * Men or postmenopausal women aged 18 to 80 * Individuals who have provided their free and informed written consent * Individuals scheduled to undergo abdominal surgery * Non-diabetic obese individuals : * Men or postmenopausal women aged 18 to 80 * BMI \> 30 - Individuals who have provided written, free, and informed consent * Scheduled to undergo abdominal surgery * Obese individuals with diabetes : * Men or postmenopausal women aged 18 to 80 with type 2 diabetes not treated with insulin or a GLP-1 agonist * BMI \> 30 * Individuals who have provided written, free, and informed consent and are scheduled to undergo abdominal surgery Exclusion Criteria : * Control group : * Individuals not enrolled in or eligible for a social security program * Individuals subject to legal guardianship (curatorship, guardianship) * Individuals subject to judicial protective measures * Pregnant women, women in labor, or breastfeeding women * Adults who are legally incapacitated or unable to give consent * Minors * BMI \> 30 * Diabetes * Chronic inflammatory disease * Cancer undergoing chemotherapy or having undergone chemotherapy within the past year * Gastrointestinal cancer with recent weight loss and/or malnutrition * Known metastatic cancers * Cancers undergoing long-term hormonal therapy * Any positive result for screening for human immunodeficiency virus (HIV) infection, hepatitis B surface antigen testing, or testing for antibodies against the hepatitis C virus (HCV) with a positive HCV RNA test. * Non-diabetic obese individuals : * Individuals not enrolled in or eligible for a social security program * Individuals subject to legal guardianship (curatorship, guardianship) * Individuals subject to judicial protective measures * Pregnant women, women in labor, or breastfeeding women * Adults who are legally incapacitated or unable to give consent * Minors * Diabetes * Chronic inflammatory disease * Cancer undergoing chemotherapy or having undergone chemotherapy within the past year * Gastrointestinal cancer with recent weight loss and/or malnutrition * Known metastatic cancers * Cancers undergoing long-term hormonal therapy, * Any positive result for screening for human immunodeficiency virus (HIV) infection, hepatitis B surface antigen, or antibodies to hepatitis C virus (HCV) with a positive HCV RNA test. * Obese individuals with diabetes * Individuals not enrolled in or not eligible for a social security program * Individuals subject to legal guardianship (curatorship, guardianship) * Individuals subject to judicial protective measures * Pregnant women, women in labor, or breastfeeding women * Adults who are legally incapacitated or unable to give consent * Minors * Diabetes * Chronic inflammatory disease * Cancer undergoing chemotherapy or having undergone chemotherapy within the past year * Gastrointestinal cancer with recent weight loss and/or malnutrition * Known metastatic cancers * Cancers undergoing long-term hormonal therapy, * Any positive result for screening for human immunodeficiency virus (HIV) infection, hepatitis B surface antigen, or antibodies against hepatitis C virus (HCV) with a positive HCV RNA test.
Where it's running
-
Chu Dijon Bourgogne
Dijon, France Recruiting
Study contacts
- Study coordinator: Bruno VERGES
- Email: bruno.verges@chu-dijon.fr
- Phone: 03.80.29.38.54
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.