How environmental fungal exposure affects asthma, ABPA, and bronchiectasis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective observational study enrolling adults aged 18–80 with diagnosed bronchial asthma (subdivided by GINA control status), ABPA, bronchiectasis, and healthy control subjects. Investigators will record detailed baseline clinical information including disease history, smoking, prior attacks and hospitalizations, and long-term medications (including inhaled corticosteroids and antifungal drugs). Environmental and lifestyle factors that may influence fungal exposure and disease control—such as indoor humidity, temperature, ventilation, pet ownership, and plant keeping—will be measured and recorded. Patient status will be tracked using questionnaires, pulmonary function, and laboratory/allergen testing.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age range of 18-80 years old (including 18 and 80 years old), gender and race are not limited;
2. No history of asthma, ABPA, or other chronic respiratory diseases.
3. No history of allergic diseases, such as allergic rhinitis, eczema, or food allergies.
4. Pulmonary function is normal or close to the normal range.
5. Laboratory testing:

1\. Blood routine: High sensitivity C-reactive protein, white blood cells, neutrophils, lymphocytes, and monocytes are all within the normal range.

Allergen testing: IgE levels for common allergens such as dust mites, cat hair, dog hair, cockroaches, mold, and pollen are normal or close to the normal range.

Exclusion Criteria:

1. Suffering from bronchial asthma ABPA、 Bronchiectasis or other respiratory diseases: chronic obstructive pulmonary disease, active pulmonary tuberculosis, pulmonary embolism, lung cancer, pneumothorax, hemoptysis, pulmonary arterial hypertension, interstitial lung disease, etc;
2. Cancer patients who suffer from serious other systemic diseases, such as myocardial infarction, stroke, hypertensive crisis or refractory hypertension, severe arrhythmia, heart failure, aortic aneurysm, liver failure, renal failure, hematological disorders, etc., and have recently been discovered or are currently receiving treatment;
3. Four weeks prior to enrollment, systemic use of antibiotics, antifungal drugs, immunosuppressants, cytotoxic agents, hormones, etc;
4. Other individuals with contraindications for induced sputum testing:

Where it's running

• The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang Recruiting
  Ningbo, Zhejiang, China Recruiting

Study contacts

• Study coordinator: Chao Cao
• Email: caocdoctor@163.com
• Phone: +86-0574-87089878

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.