How congenital hypothyroidism affects development in infants

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center observational study will examine neurological status, motor development, and sensory processing in term infants aged 6–18 months who were diagnosed with primary congenital hypothyroidism and treated from the newborn period. Participants will undergo standardized neurological and developmental examinations and structured measures of sensory processing, with results compared to age-based norms. The work is motivated by early synaptogenesis and a gap in the literature on sensory processing in this age range, complementing prior work on cognition and motor outcomes. Findings are expected to inform timelines for early follow-up and possible interventions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Those with primary congenital hypothyroidism who have been treated since the newborn period and are currently on treatment.
* Infants born at term.
* Between 6 and 18 months old.

Exclusion Criteria:

* Infants with secondary congenital hypothyroidism,
* Preterm infants,
* Those with congenital infections or proven genetic alterations,
* Infants diagnosed with metabolic, neurological, or genetic diseases,
* Infants whose parents did not volunteer for the study

Where it's running

• Nigde Omer Halisdemir University
  Niğde, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Rabia ZORLULAR
• Email: rabiaeraslan118@gmail.com
• Phone: +5424362082

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Understanding brain development in congenital hypothyroidism: comparing affected children, healthy controls, and mild thyroid conditions

  This study tests how brain development in children with congenital hypothyroidism compares to similar children without the condition and to kids with a mild thyroid finding.

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• Thyroid size in healthy, full-term newborns

  This study tests whether thyroid volume measured by ultrasound in healthy full-term newborns in Italy falls within expected ranges.

  Recruiting IRCCS Ospedale San Raffaele · Milan, Lombardy · NCT07579988

• OptiThyDose for children with congenital hypothyroidism and Graves' disease

  This trial will test whether the OptiThyDose math model helps doctors choose the right thyroid medicine dose for newborns with congenital hypothyroidism and children with Graves' disease.

  Recruiting at 6 sites University Children's Hospital Basel · Yerevan and 6 other locations · NCT06864351

• Exploring genetic causes of congenital hypothyroidism

  This study looks at the genetic causes of congenital hypothyroidism in babies born in Emilia-Romagna, Italy, to see how different genes might affect their condition and future health.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, Bologna · NCT06728735

• Comparing different levothyroxine formulations for treating congenital hypothyroidism in newborns

  This study is testing which of three different forms of levothyroxine—oral solution, liquid drops, or tablets—works best and is safest for newborns with congenital hypothyroidism.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, Bologna · NCT06724224

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.