How a meal's fat content affects brain and immune signals in healthy men
Official title: Study of the Hypothalamic Microglial Response as a Function of a Meal's Lipid Content in Humans. A Single-center Prospective Cohort Study in Healthy Male Subjects
Run by Centre Hospitalier Universitaire Dijon · NCT07557628 · Data updated 2026-11-12
This study tests how a single meal changes brain activity and immune responses in healthy men to better understand energy balance.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 20 Years and up |
| Sex | Men only |
| Enrollment | 20 (estimated) |
| Sponsor | Centre Hospitalier Universitaire Dijon Academic / other |
| Locations | 1 site (Dijon) |
| Status | Recruiting |
| Started | September 5, 2026 |
| Main results expected | September 2028 |
| Study ends | September 2028 |
| Registry record updated | September 29, 2026 |
| Trial ID | NCT07557628 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Healthy adult men aged 20 years or older with BMI 18.5–30 kg/m².
✕Probably not a fit
Individuals with diabetes, chronic inflammatory conditions, neuropsychiatric disorders, current MRI contraindications, or those on certain medications may not benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is an observational, single-center cohort study in healthy adult men. Participants provide blood samples and undergo brain MRI scans after fasting and following a meal, along with questionnaires and body composition measurements. The goal is to explore how meal-derived lipids influence hypothalamic microglia activity and systemic inflammatory responses as part of energy regulation. No intervention or treatment is being tested; the study focuses on physiological responses to eating. Data will help clarify mechanisms linking diet, brain signaling, and metabolism.
Why it matters
Potential benefit: Results may improve understanding of how meals influence brain-immune interactions related to energy balance and obesity.
How similar studies have gone: Other research has shown postprandial inflammatory responses and hypothalamic changes related to feeding; the direct link with hypothalamic microglial activity in humans is exploratory but supported by prior animal and human data.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * A person who has given oral consent * Male * Body Mass Index (BMI) between 18.5 and 30 kg/m² * Age ≥ 20 years Exclusion Criteria: * A person subject to a measure of legal protection (guardianship, tutorship) * A person subject to a judicial protective measure * A person who is not enrolled in or eligible for a social security program * Subject does not speak French * Subjects with a pacemaker or any other contraindication to MRI * Subjects with type 1 or type 2 diabetes * Subjects with a chronic inflammatory condition * Subjects with a neuropsychiatric condition * Subjects taking anti-inflammatory medication or medication that affects the central nervous system * Known hypersensitivity to foods provided during the study
Where it's running
-
Chu Dijon Bourgogne
Dijon, France Recruiting
Study contacts
- Study coordinator: Vincent SCHNEIDER
- Email: vincent.schneider@chu-dijon.fr
- Phone: 03 80 29 30 89
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.