Understanding IgE Responses in Allergic and Non-Allergic Conditions
Official title: On the Origin of Immunoglobulin E's: Elucidating the Immunological Mechanisms Underlying Mucosal IgE Responses in Type2 Disease
Run by University Hospital, Ghent · NCT06234761 · Data updated 2026-11-12
This study is trying to understand how the immune system produces IgE in people with allergic rhinitis and asthma to see how it differs from those without allergies.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | University Hospital, Ghent Academic / other |
| Drugs / interventions | dupilumab |
| Locations | 1 site (Ghent) |
| Status | Recruiting |
| Started | January 2, 2024 |
| Main results expected | December 2027 |
| Study ends | December 2028 |
| Registry record updated | September 19, 2024 |
| Trial ID | NCT06234761 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients diagnosed with nasal polyposis or allergic rhinitis.
✕Probably not a fit
Patients who have been treated with systemic corticosteroids in the last two months may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to investigate the immunological mechanisms that drive local IgE production in patients with allergic rhinitis and late-onset eosinophilic asthma. By collecting and analyzing samples from patients with chronic rhinosinusitis with nasal polyps and those with allergic rhinitis, the study seeks to elucidate the distinct pathways leading to IgE responses in these conditions. The research will utilize high-resolution single-cell sequencing to map the B cell subsets and their immune receptor profiles, providing insights into the role of IgE in disease etiology and the effects of dupilumab treatment.
Why it matters
Potential benefit: If successful, this study could lead to a better understanding of the mechanisms behind IgE-related diseases, potentially improving treatment strategies for patients.
How similar studies have gone: While the specific approach of mapping IgE B cell responses in this context may be novel, similar studies have shown promise in understanding type 2 inflammation mechanisms.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: patients with nasal polyposis - Exclusion Criteria: patients treated in the last 2 months with systemic corticosteroids \-
Where it's running
-
University Hospital Gent
Ghent, Belgium Recruiting
Study contacts
- Study coordinator: Philippe Gevaert, PHD
- Email: philippe.gevaert@ugent.be
- Phone: 003293322332
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
How a meal's fat content affects brain and immune signals in healthy men
This study tests how a single meal changes brain activity and immune responses in healthy men to better understand energy balance.
-
Understanding genetic influences and biomarkers in heart failure management
This study is trying to find new biological markers in heart failure patients to see if they can help doctors better understand who will respond to treatments and who won't.
-
Biobank for patients with cardiac arrhythmias
This study is collecting samples and information from patients with heart rhythm problems to better understand their condition and find more personalized treatment options.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.