Hospital-based look at infants under 6 months with acute malnutrition

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a hospital-based, prospective, multicenter observational cohort enrolling infants under 6 months admitted for acute malnutrition per WHO 2023 criteria. Researchers will collect standardized measurements (weight, length, head circumference, mid-upper arm circumference) and track outcomes during nutritional treatment, including recovery, growth, complications, and death over about one year across Indonesian hospitals affiliated with the HOSPIC-6 network. The study aims to describe prevalence, clinical outcomes, and factors associated with successful nutrition therapy, providing real-world data in the Indonesian context. No interventions are administered as the design is observational. Inclusion requires informed consent from guardians, and exclusions include infants with certain congenital or metabolic conditions or anatomical issues affecting weight.

Why it matters

Who can join: the full rules

Inclusion criteria:

* Infants under 6 months of age admitted to inpatient care who meet the WHO 2023 criteria for acute malnutrition.
* For infants aged 0-1 month, criteria include a documented weekly weight gain of less than 200 grams, or failure to return to birth weight by 2 weeks of chronological age.
* For infants aged 1 month to under 6 months, at least one of the following is required:

  * Weight-for-age less than -2 SD
  * Weight-for-length less than -2 SD, or
  * Mid-upper arm circumference under 110 mm (for infants older than 6 weeks), with or without nutritional oedema, and currently receiving treatment for acute malnutrition.
* Parents or legal guardians must provide written informed consent.

Exclusion criteria:

* Infants with inborn error of metabolism
* Infant with syndromic condition (e.g., Down syndrome, Silver-Russell syndrome, Turner syndrome, Klinefelter syndrome, or other diagnosed syndromic conditions),
* Infant with anatomical abnormality affecting body weight, such as hydrocephalus.

Drop Outs Criteria:

Participants will be considered "drop-outs" if they are discharged against medical advice or transferred to a non-participating hospital.

Where it's running

• RSUP Prof. Dr. I.G.N.G. Ngoerah
  Denpasar, Bali, Indonesia Recruiting
• RSUP Dr. Kariadi Semarang
  Semarang, Central Java, Indonesia Recruiting
• RS Universitas Sebelas Maret
  Sukoharjo, Central Java, Indonesia Recruiting
• RSUP Dr. Sardjito
  Yogyakarta, DI Yogyakarta, Indonesia Recruiting
• Cipto Mangunkusumo Hospital
  Jakarta Pusat, DKI Jakarta, Indonesia Recruiting
• RSIA Bunda Jakarta
  Jakarta Pusat, DKI Jakarta, Indonesia Recruiting

Study contacts

• Principal investigator: Yoga Devaera, MDPhD SpA(K)
• Study coordinator: dr. Yoga Devaera, SpA(K), PhD
• Email: yoga.devaera@ui.ac.id
• Phone: (+62) 8129431861

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.