Home-based mobile neurological check for people with brain tumors
Self-administered Remote Neurological Examination Using Mobile Application in Patients With Brain Tumors
This project will test whether people with brain tumors older than 5 can use the Iskhaa Android app to do guided self-neurological exams, upload short videos, and have an AI model detect changes that might predict neurological worsening.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 600 (estimated) |
| Ages | 5 Years and up |
| Sex | All |
| Sponsor | Tata Memorial Centre Academic / other |
| Locations | 1 site (Mumbai, Maharashtra) |
| Trial ID | NCT07236840 on ClinicalTrials.gov |
What this trial studies
This observational study develops and deploys the Iskhaa mobile application to guide patients through self-administered neurological tasks (speech, gait, limb movements) with pre-recorded video instructions and video recording. Data and videos will be stored on a secure hospital server and reviewed by investigators via mobile or desktop interfaces, while participants also complete EORTC QLQ-C30 and BN20 quality-of-life questionnaires. An AI model will be trained and validated on the recorded features to detect functional changes and predict subsequent neurological deterioration. The initial phase includes supervised onsite use (about 100 participants) at Tata Memorial Centre with subsequent remote use for eligible participants.
Who should consider this trial
Good fit: Ideal participants are people aged over 5 with a radiologic or histologic diagnosis of a brain tumor, an expected survival over six months, able to follow app instructions, and who or whose caregiver can install and use an Android smartphone app.
Not a fit: Patients with severe cognitive or psychiatric impairment, KPS/LPS below 50, expected survival under six months, unreliable caregivers, or no access to a compatible Android smartphone are unlikely to benefit from this approach.
Why it matters
Potential benefit: If successful, the app plus AI could enable earlier detection of neurological decline and more convenient remote monitoring for people with brain tumors.
How similar studies have performed: Smartphone and video-based neurological assessments have shown promise in other neurological conditions, but using recorded videos plus AI to predict deterioration specifically in brain tumor patients remains largely exploratory.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Diagnosis of brain tumors (histopathology/ radiology). 2. Age \> 5 years 3. Patient or caregiver have access to an android smart phone and is able to install the mobile application. 4. Expected survival more than 6 months during study accrual. 5. Signing patient consent or parent consent/ child assent form (as appropriate). Exclusion Criteria: 1. Patient or caregiver is not reliable to follow instructions or use the mobile application. 2. Patient with severe cognitive or psychiatric issues causing difficulty in using the app or follow instructions. 3. Karnofsky Performance Status (KPS) or Lansky Performance Status LPS) \<50. 4. Terminal illness with expected life expectancy (\<6 months).
Where this trial is running
Mumbai, Maharashtra
- Tata Memorial Centre — Mumbai, Maharashtra, India (Recruiting)
Study contacts
- Study coordinator: Dr Archya Dasgupta, Radiation Oncology, MD
- Email: archya1010@gmail.com
- Phone: 8097081506
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.