HIIT to reduce fatigue after stroke

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with chronic ischemic stroke and persistent fatigue will be randomly assigned to supervised high-intensity interval training (HIIT), moderate-intensity continuous training (MICT), or a stretching active control. Each group will attend supervised exercise sessions three times per week for 12 weeks (36 sessions total). Outcomes, including the primary measure of fatigue severity and secondary inflammatory biomarkers and health indicators, will be measured at baseline, week 6, week 12, and at a week 20 follow-up. The protocol targets ambulatory participants able to walk 10 meters with or without an aid and excludes those with major medical, neurological, or musculoskeletal conditions that would prevent safe exercise.

Why it matters

Who can join: the full rules

Inclusion criteria:

* Age of 40-80 years;
* a history of ischemic stroke resulting in unilateral limb impairment 6-60 months prior to consent to participate in the pilot trial;
* a stable medical condition;
* a subjective feeling of fatigue, defined as a period of apparent fatigue, decreased energy, increased need for rest, or fatigue out of proportion to physical activity for at least 2 weeks during the past month;
* ability to communicate with the investigators and lack of significant cognitive deficits;
* able to walk for 10 meters with or without a walking aid.

Exclusion criteria:

* An FSS score of \< 4 (20);
* other neurological conditions;
* other musculoskeletal comorbidities that would prevent safe participation in exercises;
* a medical diagnosis of significant cardiovascular, pulmonary, or metabolic disease(s);
* signs or symptoms indicative of significant cardiovascular, pulmonary, or metabolic disease(s) during the previous 3 months;
* severe lower limb spasticity (Ashworth Scale score ≥ 3);
* Botulinum toxin use in the affected lower limb within the past six months;
* current or previous use of drugs intended to resolve post-stroke fatigue;
* active engagement in other stroke rehabilitation trials.

Where it's running

• The Hong Kong Polytechnic University
  Kowloon, Hong Kong Recruiting

Study contacts

• Study coordinator: Mei Zhen Prof. Huang
• Email: mei-zhen.huang@polyu.edu.hk
• Phone: +852 00000000

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.