High vs standard protein intake in critically ill adults with acute kidney injury on CRRT

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In critically ill patients, severe illness drives muscle breakdown and weakness, especially when kidneys are injured and undergoing CRRT. The trial compares two protein feeding strategies to see if more dietary protein supports muscle preservation and recovery. Participants must be adults with AKI on CRRT and must receive enough calories enterally within the first week of ICU stay. The study is conducted at King Chulalongkorn Memorial Hospital in Bangkok and is sponsored by Chulalongkorn University. Outcomes focus on muscle-related recovery and safety of differing protein levels during critical illness.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult (≥18 years old)
* AKI receiving CRRT within 7 days after ICU admission
* Achieve and tolerate calories 70% of target daily caloric requirement (20 kcal /kg/d) within 7 days after ICU admission by enteral feeding
* Participant or their surrogates is willing and able to give informed consent for participation in the study

Exclusion Criteria:

* Moribund or withholding of treatment
* Kidney transplant recipient
* Previously diagnosed end-stage kidney disease (ESKD) currently on kidney replacement therapy
* Pregnancy or breastfeeding
* Hepatic encephalopathy (West Haven grade 3-4)
* Burn patients
* Patients whom the responsible clinician felt that the patient either needed low or high protein
* Severe complications of diabetes such as ketoacidosis, hyperosmolar coma
* Had pre-existing neuromuscular disorders
* Previously leg amputations

Where it's running

• King chula memorial hospital
  Bangkok, Bangkok, Thailand Recruiting

Study contacts

• Study coordinator: Wiphat Kittiweerawong, MD
• Email: inter.wiphat@gmail.com
• Phone: +66899496165

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.