High-Intensity Interval Training on a Stationary Bike for Walking and Function Across Different Levels of MS Disability
Official title: The Effect of High-Intensity Interval Training on Maximum Walking Distance and Functional Parameters in Patients With Multiple Sclerosis at Different Disability Levels
Run by Hacettepe University · NCT07771868 · Data updated 2026-11-12
This study tests a stationary bike HIIT program to see if it improves walking distance, fatigue, balance, strength, endurance, gait speed, and quality of life in people with multiple sclerosis across mild, moderate, and severe disability.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Hacettepe University Academic / other |
| Locations | 1 site (Hatay) |
| Status | Recruiting |
| Started | September 1, 2026 |
| Main results expected | December 31, 2027 |
| Study ends | January 31, 2028 |
| Registry record updated | September 10, 2026 |
| Trial ID | NCT07771868 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–65 with a confirmed MS diagnosis and EDSS 0–6.5 who are able to use a bicycle ergometer and meet cognitive and medical eligibility criteria.
✕Probably not a fit
Individuals with very high spasticity, recent relapse, or contraindicating medical conditions may not experience benefit from this HIIT protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study will apply a cycle ergometer-based HIIT protocol to adults with multiple sclerosis across three disability levels defined by EDSS. Participants will be assessed at baseline, immediately after the HIIT program, and 4 weeks later, focusing on outcomes such as maximum walking distance, fatigue, balance, muscle strength, endurance, gait speed, and quality of life. The aim is to determine how HIIT affects functional capacity and well-being across varying disability severities. Eligibility includes adults 18-65 with MS, EDSS 0–6.5, no recent relapse, and adequate cognitive function; several medical exclusions apply. Lead sponsorship is by Hacettepe University with the study conducted at Hatay Mustafa Kemal University in Hatay.
Why it matters
Potential benefit: If successful, the HIIT program could offer a time-efficient exercise option to improve mobility and quality of life for people with MS across different disability levels.
How similar studies have gone: Prior research in MS suggests interval training can improve exercise capacity and fatigue, supporting potential benefits for this approach, though disability-level comparisons are less well defined.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Be between the ages of 18 and 65, * Have been diagnosed with MS by a treating physician, * Have an EDSS score between 0 and 6.5, * Not having experienced a relapse within the last 3 months, * Not having severe lower extremity contractures, severe spasticity (≥3 on the Modified Ashworth Scale), or an acute orthopedic problem that would prevent the participant from pedaling on a bicycle ergometer, * Having a Mini Mental State Examination score of ≥24. Exclusion Criteria: * Having a severe cardiovascular, orthopedic, respiratory, or metabolic disease, * Having an additional neurological condition, * Being pregnant or suspecting pregnancy, * Having received a botulinum toxin injection within the last 3 months, * Having a COMPASS-31 total score greater than 13.6
Where it's running
-
Hatay Mustafa Kemal Universty
Hatay, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: İSMAİL KARA, MSc
- Email: ismailkaraa46@gmail.com
- Phone: +90 553 525 8700
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.