High-intensity aerobic exercise for fatigue in Parkinson's disease
Can High-intensity Exercise be Used to Treat Fatigue in Parkinson´s Disease?
This study tests if 12 weeks of high-intensity aerobic exercise can help reduce fatigue in people with Parkinson's disease.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 94 (estimated) |
| Ages | 40 Years and up |
| Sex | All |
| Sponsor | University of Aarhus Academic / other |
| Locations | 1 site (Aarhus, Central Jutland) |
| Trial ID | NCT06324422 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the effectiveness of 12 weeks of high-intensity aerobic exercise in reducing fatigue among individuals with Parkinson's disease. Participants will be randomly assigned to either the aerobic exercise group or a waitlist control group that will receive high-intensity resistance exercise after a 24-week period. The primary hypothesis is that those engaging in aerobic exercise will experience significant reductions in perceived fatigue compared to the control group. Follow-up assessments will be conducted to determine if these benefits are sustained over time.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 40 and older diagnosed with idiopathic Parkinson's disease who are stable in their medical treatment.
Not a fit: Patients who engage in high-intensity exercise more than twice a week or have significant medical comorbidities may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly improve the quality of life for patients with Parkinson's disease by alleviating debilitating fatigue.
How similar studies have performed: Previous studies have indicated that exercise can improve fatigue in Parkinson's disease, suggesting a potential for success with this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Minimum 40 years * Diagnosed with Idiopathic Parkinsons disease * Stable in medical treatment for six month * Able to transport themselves to and from exercise and testing sessions (with or without assistance) * H\&Y score of three or lower Exclusion criteria: * Performing high-intensity exercise more than two times per week * Significant medical comorbidities such as cardiovascular, respiratory, orthopedic, metabolic, or other neurological disorders * Cognitive dysfunction that prevents following or understanding instructions related to training and testing (answering questionnaires) * Known depression or alcohol abuse
Where this trial is running
Aarhus, Central Jutland
- Exercise Biology, Dep. of Public Health, Aarhus University — Aarhus, Central Jutland, Denmark (Recruiting)
Study contacts
- Study coordinator: Cecilie Thrue, PhD student
- Email: ceth@ph.au.dk
- Phone: +4520768102
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.