High-intensity aerobic exercise for fatigue in Parkinson's disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the effectiveness of 12 weeks of high-intensity aerobic exercise in reducing fatigue among individuals with Parkinson's disease. Participants will be randomly assigned to either the aerobic exercise group or a waitlist control group that will receive high-intensity resistance exercise after a 24-week period. The primary hypothesis is that those engaging in aerobic exercise will experience significant reductions in perceived fatigue compared to the control group. Follow-up assessments will be conducted to determine if these benefits are sustained over time.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Minimum 40 years
* Diagnosed with Idiopathic Parkinsons disease
* Stable in medical treatment for six month
* Able to transport themselves to and from exercise and testing sessions (with or without assistance)
* H\&Y score of three or lower

Exclusion criteria:

* Performing high-intensity exercise more than two times per week
* Significant medical comorbidities such as cardiovascular, respiratory, orthopedic, metabolic, or other neurological disorders
* Cognitive dysfunction that prevents following or understanding instructions related to training and testing (answering questionnaires)
* Known depression or alcohol abuse

Where it's running

• Exercise Biology, Dep. of Public Health, Aarhus University
  Aarhus, Central Jutland, Denmark Recruiting

Study contacts

• Study coordinator: Cecilie Thrue, PhD student
• Email: ceth@ph.au.dk
• Phone: +4520768102

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.