Helping Veterans with Bipolar and Substance Use Disorders after Hospitalization

Post-Hospital Intervention for Veterans With Comorbid Bipolar and Substance Use Disorders

Not applicable Interventional VA Office of Research and Development · NCT04127604

This study tests a new support program to help veterans with bipolar disorder and substance use issues stick to their treatment after leaving the hospital.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment140 (estimated)
Ages18 Years and up
SexAll
SponsorVA Office of Research and Development Federal
Locations1 site (Providence, Rhode Island)
Trial IDNCT04127604 on ClinicalTrials.gov

What this trial studies

This trial evaluates a new psychosocial intervention aimed at improving treatment adherence in Veterans who have both bipolar disorder and substance use disorders after being hospitalized. Participants will be randomly assigned to either receive the specialized intervention or an enhanced safety monitoring program, alongside their usual care. The effectiveness of these approaches will be assessed at multiple time points following discharge from the hospital, allowing for a comprehensive evaluation of outcomes.

Who should consider this trial

Good fit: Ideal candidates are Veterans diagnosed with both a mood disorder and a substance use disorder who are currently taking psychiatric medication.

Not a fit: Patients who are unable to speak and read English or are younger than 18 years old may not benefit from this study.

Why it matters

Potential benefit: If successful, this intervention could significantly improve treatment adherence and overall outcomes for Veterans with these comorbid conditions.

How similar studies have performed: Other studies have shown promise in using psychosocial interventions for similar populations, indicating potential for success in this approach.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Diagnosis of a mood disorder
* Diagnosis of a substance use disorder (drug and/or alcohol)
* Taking at least one psychiatric medication

Exclusion Criteria:

* Unable to speak and read English
* Younger than age 18

Where this trial is running

Providence, Rhode Island

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Bipolar DisorderSubstance Use DisordersTreatment AdherenceVeteransPsychosocial intervention
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.