Heart rate variability to spot sleep apnea in people with high blood pressure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective observational study will recruit adults 18–65 with hypertension or resistant hypertension and a STOP-Bang score of 3 or higher. Participants will wear a 24-hour Holter monitor to measure heart rate variability and undergo overnight polysomnography to define OSA severity. Machine learning will be used to build models linking HRV features to apnea-hypopnea index and to predict OSA risk. A subset with diagnosed OSA will be followed after treatment to see how HRV and blood pressure respond. The goal is to identify a cost-effective approach for early detection, risk stratification, and management of OSA in hypertensive patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18 to 65 years
* Diagnosed hypertension or resistant hypertension
* STOP-Bang score ≥3 indicating high risk of obstructive sleep apnea
* Willing and able to provide informed consent

Exclusion Criteria:

* Refusal to undergo HRV monitoring or polysomnography
* Unstable medical condition that may interfere with study participation
* Inability to comply with study procedures

Where it's running

• Kaohsiung Armed Forces General Hospital
  Kaohsiung City, Kaohsiung, Taiwan Recruiting

Study contacts

• Principal investigator: Yung Kuo Lee, PhD — Kaohsiung Armed Forces General Hospital
• Study coordinator: Yung Kuo Lee, PhD
• Email: abstyle0204@gmail.com
• Phone: +886910977485

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.