Heart Failure in Women: Epidemiology and Prognosis Insights

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

HER-HF is a national, prospective, multicenter observational cohort enrolling women 18 and older admitted for a first episode of heart failure at 24 Spanish hospitals. Data are collected from the index hospitalization and follow-up visits occur at 3, 6, and 12 months, with a centralized encrypted database capturing clinical, sex-specific risk factors, treatments, and patient-reported outcomes. The study records detailed pregnancy-related history, menopause details, social determinants, and treatment Dose bands to understand prognostic factors beyond traditional metrics. All participants provide informed consent, and exclusion criteria include severe frailty, cognitive impairment, terminal illness, or inability to complete follow-up. Analyses focus on associations between sex-specific variables and HF outcomes to improve understanding and care for women with HF.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Women aged 18 years or older.
* Hospital admission with a first episode of heart failure confirmed by the treating team according to current clinical practice guidelines, irrespective of left ventricular ejection fraction.
* Written informed consent given by the participant after verbal and written information.

Exclusion Criteria:

* Total functional dependence, defined as a Barthel index score of 20 or less (0-100 version).
* Moderate-to-severe cognitive impairment, defined as 5 or more errors on the Pfeiffer questionnaire, adjusted for educational attainment.
* Severe frailty, defined as a Clinical Frailty Scale score of 6 or more.
* Terminal illness unrelated to heart failure with an expected survival of less than 6 months according to clinical judgment.
* Inability to complete clinical follow-up or subsequent contact (for example, no contact details available, or transfer to a center outside the network).
* Any previous diagnosis of heart failure.

Where it's running

• Complexo Hospitalario Universitario A Coruna
  A Coruña, A Coruna, Spain Recruiting
• Hospital Clinico Universitario de Santiago de Compostela
  Santiago de Compostela, A Coruna, Spain Recruiting
• Hospital Universitario de Badajoz
  Badajoz, Badajoz, Spain Recruiting
• Hospital Universitario de Burgos
  Burgos, Burgos, Spain Recruiting
• Hospital Universitario de Caceres
  Cáceres, Caceres, Spain Recruiting
• Hospital Universitario Puerta del Mar
  Cadiz, Cadiz, Spain Recruiting

Study contacts

• Principal investigator: Carolina Ortiz Cortes, MD — Hospital Universitario Fundacion Alcorcon
• Study coordinator: Carolina Ortiz Cortes, MD
• Email: carol.ortizcortes@secardiologia.es
• Phone: +34 91 621 94 00

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.