Gut microbiota changes after an ischemic stroke.
Official title: Investigation Into the Gut Microbiota-Immune-Inflammatory Interaction Network and Its Mechanisms in Patients With Ischemic Stroke
Run by Affiliated Hospital of Nantong University · NCT07247838 · Data updated 2026-11-12
This study will test whether and how gut bacteria change after a first acute ischemic stroke and whether those changes relate to recovery in adults admitted within 48 hours of symptom onset.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | Affiliated Hospital of Nantong University Academic / other |
| Locations | 1 site (Nantong, Jiangsu) |
| Status | Recruiting |
| Started | November 19, 2025 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2028 |
| Registry record updated | December 9, 2025 |
| Trial ID | NCT07247838 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults (≥18) with a first acute ischemic stroke, NIHSS score ≥4, who can provide an initial stool sample within 48 hours of symptom onset, can give informed consent, and have not used antibiotics or probiotics in the prior month.
✕Probably not a fit
Patients who recently used antibiotics or probiotics, have active infections, major organ dysfunction, prior major gastrointestinal disease, cannot provide stool samples, or cannot consent are unlikely to benefit from this observational protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective observational cohort with control elements that will collect stool samples shortly after hospital admission and during follow-up to profile gut microbiota. Participants are first-time acute ischemic stroke patients admitted within 48 hours, with NIHSS ≥4, and those who recently used antibiotics or probiotics are excluded. The study will compare microbiota composition over time and correlate microbial signatures with clinical outcomes such as neurological status and functional recovery at three months. The work is conducted at the Affiliated Hospital of Nantong University with collaboration from Zhejiang University.
Why it matters
Potential benefit: If successful, the study could identify microbial patterns linked to better or worse recovery and point toward microbiome-based prevention or therapy strategies.
How similar studies have gone: Previous observational studies have reported links between gut microbiota composition and stroke outcomes, but prospective cohort data are limited and interventional proof remains sparse.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: (1) First-time acute ischemic stroke patients must have completed initial sample collection within 48 hours of symptom onset and hospital admission; (2) Participants must be aged 18 or older, with no gender restrictions; (3) Stroke patients must have a National Institutes of Health Stroke Scale (NIHSS) score of 4 or higher; (4) Participants must fully understand the study protocol and provide informed consent. Exclusion Criteria: (1) Patients who have taken antibiotics or probiotics within one month prior to hospitalization or during follow-up; (2) Patients with infectious diseases such as pneumonia or urinary tract infections; (3) Patients who cannot obtain stool samples within three days after hospitalization or during three-month follow-up; (4) Patients with severe dysfunction of major organs including heart, lungs, liver, or kidneys; (5) Patients who have not provided or are unable to provide informed consent; (6) Patients with a history of major gastrointestinal diseases; (7) Patients with other severe neurological disorders; (8) Patients deemed unsuitable by investigators to participate in this clinical study.
Where it's running
-
Affiliated Hospital of Affiliated Hospital
Nantong, Jiangsu, China Recruiting
Study contacts
- Principal investigator: Xiao MB Director of scientific research Department, Doctor — Affiliated Hospital of Nantong University
- Study coordinator: Gao YT Director of the Department of Anesthesiology, Master
- Email: gyt19700114@sina.com
- Phone: 13962988003
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
AI-based tools to help diagnose, treat and predict stroke outcomes across multiple hospitals
This study tests AI-powered tools on real-world stroke patients to see if they can improve pre-hospital triage, diagnosis, and outcome prediction while data stay securely within each hospital.
-
Remote ischemic conditioning for post-stroke insomnia
A 136-person, randomized study will test whether a non-invasive arm-cuff procedure done twice daily for 90 days can improve sleep after a first ischemic stroke in adults 18–80.
-
Ear-based nerve stimulation to help sleep after a stroke
A device that delivers vagal nerve stimulation through the ear is tested to see if it helps stroke patients in rehab sleep better.
-
Theta Burst Stimulation to Help Stroke Recovery (Upper and Lower Limbs)
This trial tests whether applying theta burst stimulation to the motor cortex, in combination with standard rehabilitation, helps people over 45 who recently had a first ischemic stroke recover arm and leg movement.
-
Preventing another ischemic stroke with a smart bracelet and app
This study tests whether a digital prevention program using a wearable and a mobile app can help people who recently had an ischemic stroke reduce the chance of another stroke and improve risk-factor control.
-
Photon-counting CT to check intracranial stents
This study tests whether ultra-high-resolution photon-counting CT can reliably visualize intracranial stents and detect in-stent restenosis during follow-up of patients with prior stents.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.