Green tea extract gel added to standard care for stage II periodontitis
Official title: Effectiveness of Epigallocatechin-3-Gallate (Green Tea Extract) as Adjunctive Locally Delivered Nanotherapeutic in the Treatment of Stage II Periodontitis (A Randomized Controlled Clinical Trial)Man
Run by Mansoura University · NCT07754253 · Data updated 2026-11-12
This study tests whether a green tea extract gel packaged in tiny particles, placed in gum pockets after cleaning, helps reduce pocket depth in people with stage II periodontitis.
Quick facts
| Phase | Phase 1 |
|---|---|
| Study type | Interventional |
| Ages | 25 Years to 60 Years |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Mansoura University Academic / other |
| Locations | 1 site (Al Mansurah, Dakahlia Governorate) |
| Status | Recruiting |
| Started | March 16, 2026 |
| Main results expected | August 17, 2026 |
| Study ends | December 20, 2026 |
| Registry record updated | August 10, 2026 |
| Trial ID | NCT07754253 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 25–60 with stage II periodontitis (pocket depth ≤ 5 mm, CAL 3–4 mm), good plaque control, and consent willing to participate.
✕Probably not a fit
Patients with active systemic disease, recent periodontal therapy, recent antibiotic/anti-inflammatory use, pregnancy, lactation, or smoking may not benefit from this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This early-phase interventional trial investigates the local delivery of epigallocatechin-3-gallate (EGCG)–loaded chitosan nanoparticulate gel as an adjunct to scaling and root planing. Ten adults with stage II periodontitis will receive the EGCG gel into periodontal pockets in addition to standard debridement, with comparisons to debridement alone. Primary outcome is pocket depth reduction at 3 months; secondary outcomes include clinical attachment level, bleeding on probing, plaque, gingival indices, and gingival crevicular fluid TNF-α. The study explores biochemically relevant changes alongside clinical measures to assess anti-inflammatory and periodontal healing effects.
Why it matters
Potential benefit: If successful, participants may experience greater pocket depth reduction and improved periodontal health when EGCG gel is used with standard cleaning.
How similar studies have gone: Prior work in local antimicrobial and anti-inflammatory strategies for periodontitis supports potential benefit, but this exact EGCG-loaded nanoparticulate gel approach is novel in this setting.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Healthy patients diagnosed with stage II and grade B periodontitis (pocket depth ≤ 5mm and CAL = 3-4 mm). * Patients within the age range of 25-60 years. * Good compliance with the plaque control instructions following initial therapy. 9 * Patients willing to participate in the study and will give written informed consent. Exclusion Criteria: * Patients with active systemic disease. * Periodontal treatment during the last 6 months. * Patients with a history of antibiotic use or anti-inflammatory drugs during the previous 3 months prior to the study. * Pregnant and lactating females. * Smokers
Where it's running
-
Mansoura university
Al Mansurah, Dakahlia Governorate, Egypt Recruiting
Study contacts
- Study coordinator: Mohamed Ghanem Aldhafeeri
- Email: Dr.m.aldhafeeri@gmail.com
- Phone: 0021500676990
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.