GLP-1 medicines for upper and lower limb lymphedema

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an early-phase, investigator-initiated interventional study testing GLP-1 receptor agonists in adults with unilateral upper or lower extremity lymphedema. Eligible participants must be ≥18 years old with limb volume >5% and BMI ≥23, and those with a cancer history require oncology clearance. Key exclusions include moderate-to-severe venous insufficiency, current GLP-1 use, or contraindications such as MEN syndrome or prior thyroid cancer. Outcomes will focus on clinical measures of lymphedema and patient-reported quality of life, with study visits conducted at two New Jersey sites.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Adults 18 years or older with unilateral upper or lower extremity lymphedema Limb volume \> 5% BMI =\> 23 Oncology clearance if there is a cancer history

Exclusion Criteria:

Moderate to severe venous insufficiency Actively using GLP-1 RAs Known intolerance or adverse effect to GLP-1 RAs Medical history or morbidity where GLP-1 RAs are contraindicated as per patient's primary care provider such as MEN syndrome or history of thyroid cancer.

Where it's running

• River Center
  Red Bank, New Jersey, United States Recruiting
• 260 Old Hook Rd Suite 304
  Westwood, New Jersey, United States Recruiting

Study contacts

• Study coordinator: Giana Truax
• Email: gtruax@sycamoremm.com
• Phone: 866-266-2577

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.