Ginger-enriched beverage for inflammation, oxidative stress, and vascular health

Study of the Effect of a Ginger-based Functional Beverage on Markers of Inflammation, Oxidative Stress, and Endothelial Damage.

This trial will test whether drinking a ginger-enriched beverage every day for 60 days can lower inflammation, reduce oxidative stress, and improve blood vessel function in adults with excess body fat.

Quick facts

• Phase: NA
• Study type: Interventional
• Enrollment: 50 (estimated)
• Ages: 23 Years to 65 Years
• Sex: All
• Sponsor: Universidad Católica San Antonio de Murcia (other)
• Locations: 1 site (Murcia)
• Trial ID: NCT07433998 on ClinicalTrials.gov

What this trial studies

This randomized, double-blind, parallel, placebo-controlled trial assigns adults with excess adiposity to drink either a functional beverage enriched with ginger or a matched control beverage daily for 60 days. Investigators will measure blood markers of inflammation and oxidative stress, as well as indicators of endothelial (blood vessel) damage and cardiometabolic risk factors before and after the intervention. Participants are 23–65 years old with BMI >27.5 kg/m² and must be free of diagnosed chronic diseases and regular pharmacological or supplement use. Random allocation and blinding are used to reduce bias between the ginger and placebo groups.

Who should consider this trial

Good fit: Adults aged 23–65 with BMI over 27.5 kg/m² who do not have diagnosed chronic diseases, are not taking regular medications or dietary supplements, are not pregnant or breastfeeding, and can comply with study visits are ideal candidates.

Not a fit: People with chronic diseases, regular pharmacologic treatment or supplement use, current smokers, pregnant or breastfeeding individuals, those on active weight-loss diets, or recent major surgery patients are unlikely to be eligible or to gain benefit from this intervention.

Why it matters

Potential benefit: If effective, daily consumption of a ginger-enriched beverage could modestly reduce inflammation and oxidative stress and improve vascular health in adults with excess adiposity, potentially lowering cardiometabolic risk.

How similar studies have performed: Small clinical trials and laboratory studies have suggested ginger can lower some inflammatory and oxidative stress markers, but robust randomized evidence in adults with excess adiposity is still limited.

Eligibility criteria

Inclusion Criteria:

* Male and female participants.
* Age between 23 and 65 years.
* Body mass index (BMI) \> 27.5 kg/m².
* Absence of diagnosed chronic diseases.
* Not receiving pharmacological treatment or dietary supplementation on a regular basis.
* Ability to understand the study procedures and willingness to comply with study requirements.

Exclusion Criteria:

* Presence of acute or chronic diseases not specified in the inclusion criteria.
* Ongoing chronic pharmacological treatment or active use of dietary supplements.
* Major surgery within the previous three months.
* Current smokers or recent former smokers (less than six months since cessation).
* History of clinically relevant food allergies or eating disorders.
* Concurrent participation in another clinical trial or research study.
* Pregnancy or breastfeeding.
* Following an active weight-loss diet.
* Investigator's judgment of unsuitability for study participation.

Where this trial is running

Murcia

• UCAM — Murcia, Spain (RECRUITING)

Study contacts

• Principal investigator: JAvier Marhuenda Hernández — Universidad Católica San Antonio de Murcia
• Study coordinator: Javier Marhuenda Hernández

Conditions: Inflammation Biomarkers, Oxidative Stress, Cardiometabolic Risk Factors, inflammation Biomarkers, Randomized Controlled Trial, Ginger